Abstract：
UNASSIGNED: Reduced activity of the sucrase-isomaltase (SI) enzyme can cause gastrointestinal symptoms. Biochemical measurement of SI activity in small intestinal biopsies is presently considered the gold standard for the diagnosis of SI deficiency, but this invasive test is not suitable as a routine diagnostic tool.
UNASSIGNED: To evaluate a 13C-sucrose-breath test (13CSBT) as a diagnostic tool for SI deficiency in an adult population.
UNASSIGNED: 13CSBT results were compared to sucrase activity measured in duodenal biopsies.
UNASSIGNED: Forty patients with gastrointestinal symptoms were included in the study, 4 of whom had celiac disease and the rest (n = 36) had normal histological findings. Nine patients (22.5%) had low sucrase activity measured using duodenal biopsies. No correlation was observed between enzymatic sucrase activity and the 13CSBT results. The 13CSBT-curves for the celiac patients versus patients with normal duodenal histology demonstrated that the patients with celiac disease were within the lower range of the distribution.
UNASSIGNED: We observed a mismatch between the 13CSBT results and the biochemically measured sucrase activity, suggesting that SI activity is not uniformly distributed throughout the small intestines. This methodological discrepancy should be acknowledged when diagnosing SI deficiency.
UNASSIGNED: To evaluate a 13C-sucrose-breath test (13CSBT) as a diagnostic tool for SI deficiency in an adult population.
UNASSIGNED: 13CSBT results were compared to sucrase activity measured in duodenal biopsies.
UNASSIGNED: Forty patients with gastrointestinal symptoms were included in the study, 4 of whom had celiac disease and the rest (n = 36) had normal histological findings. Nine patients (22.5%) had low sucrase activity measured using duodenal biopsies. No correlation was observed between enzymatic sucrase activity and the 13CSBT results. The 13CSBT-curves for the celiac patients versus patients with normal duodenal histology demonstrated that the patients with celiac disease were within the lower range of the distribution.
UNASSIGNED: We observed a mismatch between the 13CSBT results and the biochemically measured sucrase activity, suggesting that SI activity is not uniformly distributed throughout the small intestines. This methodological discrepancy should be acknowledged when diagnosing SI deficiency.
摘要：
■蔗糖酶-异麦芽糖酶（SI）的活性降低会引起胃肠道症状。目前，小肠活检中SI活性的生化测量被认为是诊断SI缺陷的金标准。但是这种侵入性测试不适合作为常规诊断工具。
■评估13C-蔗糖呼气试验（13CSBT）作为成年人群SI缺乏症的诊断工具。
■将13CSBT结果与十二指肠活检中测量的蔗糖酶活性进行比较。
■40例有胃肠道症状的患者被纳入研究，其中4人患有乳糜泻，其余（n=36）的组织学检查结果正常。9例患者（22.5％）的蔗糖酶活性较低，使用十二指肠活检进行了测量。在酶促蔗糖酶活性和13CSBT结果之间没有观察到相关性。乳糜泻患者与十二指肠组织学正常患者的13CSBT曲线表明，乳糜泻患者在较低的分布范围内。
■我们观察到13CSBT结果与生化测量的蔗糖酶活性之间存在不匹配，这表明SI活性在整个小肠中分布不均匀。在诊断SI缺陷时应承认这种方法上的差异。
■评估13C-蔗糖呼气试验（13CSBT）作为成年人群SI缺乏症的诊断工具。
■将13CSBT结果与十二指肠活检中测量的蔗糖酶活性进行比较。
■40例有胃肠道症状的患者被纳入研究，其中4人患有乳糜泻，其余（n=36）的组织学检查结果正常。9例患者（22.5％）的蔗糖酶活性较低，使用十二指肠活检进行了测量。在酶促蔗糖酶活性和13CSBT结果之间没有观察到相关性。乳糜泻患者与十二指肠组织学正常患者的13CSBT曲线表明，乳糜泻患者在较低的分布范围内。
■我们观察到13CSBT结果与生化测量的蔗糖酶活性之间存在不匹配，这表明SI活性在整个小肠中分布不均匀。在诊断SI缺陷时应承认这种方法上的差异。
