Abstract：
This study utilized Mendelian randomization to explore the impact of hypertensive disorders of pregnancy and their subtypes on brain structures, using genome-wide association study data from the FinnGen consortium for hypertensive disorders of pregnancy exposure and brain structure data from the ENIGMA consortium as outcomes. The inverse-variance weighted method, along with Cochran\'s Q test, Mendelian randomization-Egger regression, Mendelian randomization-PRESSO global test, and the leave-one-out approach, were applied to infer causality and assess heterogeneity and pleiotropy. Findings indicate hypertensive disorders of pregnancy are associated with structural brain alterations, including reduced cortical thickness in areas like the insula, isthmus cingulate gyrus, superior temporal gyrus, temporal pole, and transverse temporal gyrus, and an increased surface area in the superior frontal gyrus. Specific associations were found for hypertensive disorders of pregnancy subtypes: chronic hypertension with superimposed preeclampsia increased cortical thickness in the supramarginal gyrus; preeclampsia/eclampsia led to thinner cortex in the lingual gyrus and larger hippocampal volume and superior parietal lobule surface area. Chronic hypertension was associated with reduced cortical thickness in the caudal and rostral anterior cingulate and increased surface area of the cuneus and thickness of the pars orbitalis cortex. Gestational hypertension showed no significant brain region changes. These insights clarify hypertensive disorders of pregnancies\' neurological and cognitive effects by identifying affected brain regions.
摘要：
本研究利用孟德尔随机化来探讨妊娠期高血压疾病及其亚型对脑结构的影响。使用来自FinnGen联盟的全基因组关联研究数据对妊娠高血压疾病的暴露和来自ENIGMA联盟的脑结构数据作为结局.逆方差加权法，连同Cochran的Q测试,孟德尔随机化-Egger回归，孟德尔随机化-PRESSO全局检验，和留一法，用于推断因果关系，评估异质性和多效性。研究结果表明，妊娠期高血压疾病与大脑结构改变有关，包括减少脑岛等区域的皮质厚度，峡部扣带回，颞上回,颞极,和颞横回,额上回的表面积增加。在妊娠亚型高血压疾病中发现了特定的关联：慢性高血压合并先兆子痫增加了颈上回的皮质厚度；先兆子痫/子痫导致舌回皮质变薄，海马体积增大和顶叶上小叶表面积增大。慢性高血压与尾端和头端前扣带回的皮质厚度减少，and骨的表面积和眼眶皮质的厚度增加有关。妊娠期高血压患者脑区无明显改变。这些见解通过识别受影响的大脑区域来阐明妊娠高血压疾病的神经和认知作用。
