Abstract：
BACKGROUND: Higher neuroticism might be associated with dementia risk. Here we investigated modification by genetic predisposition to dementia, mediation by mental health and vascular conditions, neuroimaging outcomes, and cognitive function.
METHODS: Cox proportional-hazards models were used to assess the association between neuroticism score and incident dementia over up to 15 years in 1,74,164 participants. Cross-sectional analyses on dementia-related neuroimaging outcomes and cognitive function were conducted in 39,459 dementia-free participants.
RESULTS: Higher neuroticism was associated with an 11% higher risk of incident dementia, especially vascular dementia (15% higher risk), regardless of genetic predisposition to dementia. Mental and vascular conditions mediated the association of neuroticism with all-cause dementia and vascular dementia. Neuroticism was associated with higher cerebrovascular pathology, lower gray matter volume, and worse function across multiple cognitive domains.
CONCLUSIONS: Neuroticism could represent a risk factor for dementia, and vascular and mental health might drive these associations.
CONCLUSIONS: Neuroticism was associated with an increased risk of incident all-cause dementia, particularly vascular dementia. Associations were not modified by genetic predisposition to dementia. Associations were largely mediated by mental and vascular conditions. Neuroticism was associated with increased cerebrovascular pathology and lower gray matter volume. Neuroticism was associated with worse function across multiple cognitive domains.
METHODS: Cox proportional-hazards models were used to assess the association between neuroticism score and incident dementia over up to 15 years in 1,74,164 participants. Cross-sectional analyses on dementia-related neuroimaging outcomes and cognitive function were conducted in 39,459 dementia-free participants.
RESULTS: Higher neuroticism was associated with an 11% higher risk of incident dementia, especially vascular dementia (15% higher risk), regardless of genetic predisposition to dementia. Mental and vascular conditions mediated the association of neuroticism with all-cause dementia and vascular dementia. Neuroticism was associated with higher cerebrovascular pathology, lower gray matter volume, and worse function across multiple cognitive domains.
CONCLUSIONS: Neuroticism could represent a risk factor for dementia, and vascular and mental health might drive these associations.
CONCLUSIONS: Neuroticism was associated with an increased risk of incident all-cause dementia, particularly vascular dementia. Associations were not modified by genetic predisposition to dementia. Associations were largely mediated by mental and vascular conditions. Neuroticism was associated with increased cerebrovascular pathology and lower gray matter volume. Neuroticism was associated with worse function across multiple cognitive domains.
摘要：
背景：较高的神经质可能与痴呆风险有关。在这里，我们调查了痴呆症的遗传易感性，通过心理健康和血管疾病进行调解，神经影像学结果，和认知功能。
方法：在1,74,164名参与者中，使用Cox比例风险模型评估了长达15年的神经质评分与痴呆之间的关联。对39,459名无痴呆参与者进行了与痴呆相关的神经影像学结果和认知功能的横断面分析。
结果：较高的神经质与发生痴呆的风险增加11％有关，尤其是血管性痴呆（风险高15%），不管痴呆症的遗传倾向。精神和血管疾病介导了神经质与全因痴呆和血管性痴呆的关联。神经质与较高的脑血管病理有关，降低灰质体积，在多个认知领域的功能更差。
结论：神经质可能是痴呆的危险因素，血管和心理健康可能会推动这些联系。
结论：神经质与全因痴呆的发病风险增加有关，尤其是血管性痴呆.关联并未因痴呆症的遗传易感性而改变。关联主要由精神和血管疾病介导。神经质与脑血管病理增加和灰质体积降低有关。神经质与多个认知领域的功能较差有关。
方法：在1,74,164名参与者中，使用Cox比例风险模型评估了长达15年的神经质评分与痴呆之间的关联。对39,459名无痴呆参与者进行了与痴呆相关的神经影像学结果和认知功能的横断面分析。
结果：较高的神经质与发生痴呆的风险增加11％有关，尤其是血管性痴呆（风险高15%），不管痴呆症的遗传倾向。精神和血管疾病介导了神经质与全因痴呆和血管性痴呆的关联。神经质与较高的脑血管病理有关，降低灰质体积，在多个认知领域的功能更差。
结论：神经质可能是痴呆的危险因素，血管和心理健康可能会推动这些联系。
结论：神经质与全因痴呆的发病风险增加有关，尤其是血管性痴呆.关联并未因痴呆症的遗传易感性而改变。关联主要由精神和血管疾病介导。神经质与脑血管病理增加和灰质体积降低有关。神经质与多个认知领域的功能较差有关。
