Abstract：
Artificial metallo-nucleases (AMNs) are small molecule DNA cleavage agents, also known as DNA molecular scissors, and represent an important class of chemotherapeutic with high clinical potential. This review provides a primary level of exploration on the concepts key to this area including an introduction to DNA structure, function, recognition, along with damage and repair mechanisms. Building on this foundation, we describe hybrid molecules where AMNs are covalently attached to directing groups that provide molecular scissors with enhanced or sequence specific DNA damaging capabilities. As this research field continues to evolve, understanding the applications of AMNs along with synthetic conjugation strategies can provide the basis for future innovations, particularly for designing new artificial gene editing systems.
摘要：
人工金属核酸酶（AMNs）是小分子DNA裂解剂，也被称为DNA分子剪刀，代表一类重要的化疗药物，具有很高的临床潜力。这篇综述提供了对该领域关键概念的初步探索，包括对DNA结构的介绍，函数,认可,以及损坏和修复机制。建立在这个基础上，我们描述了杂交分子，其中AMN共价连接到指导基团，这些指导基团提供具有增强或序列特异性DNA损伤能力的分子剪刀。随着这个研究领域的不断发展，了解AMN的应用以及合成共轭策略可以为未来的创新提供基础，特别是设计新的人工基因编辑系统。
