PDF(Pubmed)
Abstract：
UNASSIGNED: This study aims to investigate the effects of coronary collateral circulation (CCC) on the prognosis of chronic total occlusion (CTO) patients with or without metabolic syndrome (MetS).
UNASSIGNED: The study included 342 CTO patients who underwent successful percutaneous coronary intervention at the People\'s Hospital of Liaoning Province between 1 February 2021 and 30 September 2023. The Rentrop score was used to assess the status of CCC. The outcome was major adverse cardiovascular and cerebrovascular events (MACCEs), defined as a composite of all-cause mortality, cardiac death, non-fatal myocardial infarction (MI), target vessel revascularization (TVR), and non-fatal stroke. Univariate and multivariate logistic analyses were used to investigate the association of CCC, MetS, and MACCEs with odds ratios (ORs) and 95% confidence intervals (CIs). The effect of CCC was further investigated in different MetS, diabetes mellitus (DM), and Syntax score groups.
UNASSIGNED: MACCEs were more common in patients with poor CCC compared to those with good CCC (38.74% vs. 16.56%). Statistical differences were found in MACCEs (OR = 3.33, 95% CI: 1.93-5.72), MI (OR = 3.11, 95% CI: 1.73-5.58), TVR (OR = 3.06, 95% CI: 1.70-5.53), and stent thrombosis (OR = 6.14, 95% CI: 2.76-13.65) between the good and poor CCC groups. Poor CCC patients with MetS had a higher incidence of MACCEs (OR = 4.21, 95% CI: 2.05-8.65), non-fatal MI (OR = 4.44, 95% CI: 2.01-9.83), TVR (OR = 3.28, 95% CI: 1.51-7.11), and stent thrombosis (OR = 10.80, 95% CI: 3.11-37.54). Similar findings were also observed in CTO patients with DM and a Syntax score ≥23.
UNASSIGNED: Poor CCC could increase the risk of MACCEs in CTO patients, particularly those with MetS, DM, and a Syntax score ≥23. Further prospective, multicenter studies are needed to validate our findings and to explore potential therapeutic interventions.
UNASSIGNED: The study included 342 CTO patients who underwent successful percutaneous coronary intervention at the People\'s Hospital of Liaoning Province between 1 February 2021 and 30 September 2023. The Rentrop score was used to assess the status of CCC. The outcome was major adverse cardiovascular and cerebrovascular events (MACCEs), defined as a composite of all-cause mortality, cardiac death, non-fatal myocardial infarction (MI), target vessel revascularization (TVR), and non-fatal stroke. Univariate and multivariate logistic analyses were used to investigate the association of CCC, MetS, and MACCEs with odds ratios (ORs) and 95% confidence intervals (CIs). The effect of CCC was further investigated in different MetS, diabetes mellitus (DM), and Syntax score groups.
UNASSIGNED: MACCEs were more common in patients with poor CCC compared to those with good CCC (38.74% vs. 16.56%). Statistical differences were found in MACCEs (OR = 3.33, 95% CI: 1.93-5.72), MI (OR = 3.11, 95% CI: 1.73-5.58), TVR (OR = 3.06, 95% CI: 1.70-5.53), and stent thrombosis (OR = 6.14, 95% CI: 2.76-13.65) between the good and poor CCC groups. Poor CCC patients with MetS had a higher incidence of MACCEs (OR = 4.21, 95% CI: 2.05-8.65), non-fatal MI (OR = 4.44, 95% CI: 2.01-9.83), TVR (OR = 3.28, 95% CI: 1.51-7.11), and stent thrombosis (OR = 10.80, 95% CI: 3.11-37.54). Similar findings were also observed in CTO patients with DM and a Syntax score ≥23.
UNASSIGNED: Poor CCC could increase the risk of MACCEs in CTO patients, particularly those with MetS, DM, and a Syntax score ≥23. Further prospective, multicenter studies are needed to validate our findings and to explore potential therapeutic interventions.
摘要：
■本研究旨在探讨冠状动脉侧支循环（CCC）对患有或不患有代谢综合征（MetS）的慢性完全闭塞（CTO）患者预后的影响。
该研究纳入了342名CTO患者，他们在2021年2月1日至2023年9月30日期间在辽宁省人民医院成功进行了经皮冠状动脉介入治疗。Rentrop评分用于评估CCC的状态。结果为主要不良心脑血管事件（MACCEs），定义为全因死亡率的综合，心脏死亡,非致死性心肌梗死(MI),靶血管血运重建(TVR),和非致命性中风。单变量和多变量逻辑分析用于研究CCC的关联，MetS,以及具有比值比(OR)和95%置信区间(CI)的MACCE。在不同的MetS中进一步研究了CCC的作用，糖尿病（DM），和语法评分组。
■与CCC良好的患者相比，CCC较差的患者更常见（38.74％vs.16.56%）。在MACCE中发现了统计学差异(OR=3.33，95%CI：1.93-5.72)，MI(OR=3.11，95%CI：1.73-5.58)，TVR（OR=3.06，95%CI：1.70-5.53），良好和不良CCC组之间的支架内血栓形成（OR=6.14，95％CI：2.76-13.65）。不良CCC患者的MACCE发生率较高（OR=4.21，95％CI：2.05-8.65），非致死性MI（OR=4.44，95%CI：2.01-9.83），TVR（OR=3.28，95%CI：1.51-7.11），支架内血栓形成（OR=10.80，95%CI：3.11～37.54）。在糖尿病和语法评分≥23的CTO患者中也观察到类似的发现。
■不良的CCC可能会增加CTO患者的MACCE风险，尤其是那些有MetS的人，DM,语法评分≥23。进一步的前瞻性，需要多中心研究来验证我们的发现并探索潜在的治疗干预措施。
该研究纳入了342名CTO患者，他们在2021年2月1日至2023年9月30日期间在辽宁省人民医院成功进行了经皮冠状动脉介入治疗。Rentrop评分用于评估CCC的状态。结果为主要不良心脑血管事件（MACCEs），定义为全因死亡率的综合，心脏死亡,非致死性心肌梗死(MI),靶血管血运重建(TVR),和非致命性中风。单变量和多变量逻辑分析用于研究CCC的关联，MetS,以及具有比值比(OR)和95%置信区间(CI)的MACCE。在不同的MetS中进一步研究了CCC的作用，糖尿病（DM），和语法评分组。
■与CCC良好的患者相比，CCC较差的患者更常见（38.74％vs.16.56%）。在MACCE中发现了统计学差异(OR=3.33，95%CI：1.93-5.72)，MI(OR=3.11，95%CI：1.73-5.58)，TVR（OR=3.06，95%CI：1.70-5.53），良好和不良CCC组之间的支架内血栓形成（OR=6.14，95％CI：2.76-13.65）。不良CCC患者的MACCE发生率较高（OR=4.21，95％CI：2.05-8.65），非致死性MI（OR=4.44，95%CI：2.01-9.83），TVR（OR=3.28，95%CI：1.51-7.11），支架内血栓形成（OR=10.80，95%CI：3.11～37.54）。在糖尿病和语法评分≥23的CTO患者中也观察到类似的发现。
■不良的CCC可能会增加CTO患者的MACCE风险，尤其是那些有MetS的人，DM,语法评分≥23。进一步的前瞻性，需要多中心研究来验证我们的发现并探索潜在的治疗干预措施。
