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Abstract：
BACKGROUND: Patients with ankylosing spondylitis (AS) frequently suffer from comorbid sleep disorders, exacerbating the burden of the disease and affecting their quality of life.
OBJECTIVE: To investigate the clinical significance of serum inflammatory factors, health index and disease activity scores in patients with AS complicated by sleep disorders.
METHODS: A total of 106 AS patients with comorbid sleep disorders were included in the study. The patients were grouped into the desirable and undesirable prognosis groups in accordance with their clinical outcomes. The serum levels of inflammatory factors, including C-reactive protein, erythrocyte sedimentation rate, interleukin (IL)-6, tumour necrosis factor-α and IL-1β, were measured. Disease activity scores, such as the Bath AS functional index, Bath AS disease activity index, Bath AS metrology index and AS disease activity score, were assessed. The health index was obtained through the Short Form-36 questionnaire.
RESULTS: The study found significant associations amongst serum inflammatory factors, health index and disease activity scores in AS patients with comorbid sleep disorders. Positive correlations were found between serum inflammatory factors and disease activity scores, indicating the influence of heightened systemic inflammation on disease severity and functional impairment. Conversely, negative correlations were found between disease activity scores and health index parameters, highlighting the effect of disease activity on various aspects of health-related quality of life. Logistic regression analysis further confirmed the predictive value of these factors on patient outcomes, underscoring their potential utility in risk assessment and prognostication.
CONCLUSIONS: The findings demonstrate the intricate interplay amongst disease activity, systemic inflammation and patient-reported health outcomes in AS patients complicated by sleep disorders. The results emphasise the need for comprehensive care strategies that address the diverse needs and challenges faced by these patients and underscore the potential relevance of serum inflammatory factors, health index and disease activity scores as prognostic markers in this patient population.
OBJECTIVE: To investigate the clinical significance of serum inflammatory factors, health index and disease activity scores in patients with AS complicated by sleep disorders.
METHODS: A total of 106 AS patients with comorbid sleep disorders were included in the study. The patients were grouped into the desirable and undesirable prognosis groups in accordance with their clinical outcomes. The serum levels of inflammatory factors, including C-reactive protein, erythrocyte sedimentation rate, interleukin (IL)-6, tumour necrosis factor-α and IL-1β, were measured. Disease activity scores, such as the Bath AS functional index, Bath AS disease activity index, Bath AS metrology index and AS disease activity score, were assessed. The health index was obtained through the Short Form-36 questionnaire.
RESULTS: The study found significant associations amongst serum inflammatory factors, health index and disease activity scores in AS patients with comorbid sleep disorders. Positive correlations were found between serum inflammatory factors and disease activity scores, indicating the influence of heightened systemic inflammation on disease severity and functional impairment. Conversely, negative correlations were found between disease activity scores and health index parameters, highlighting the effect of disease activity on various aspects of health-related quality of life. Logistic regression analysis further confirmed the predictive value of these factors on patient outcomes, underscoring their potential utility in risk assessment and prognostication.
CONCLUSIONS: The findings demonstrate the intricate interplay amongst disease activity, systemic inflammation and patient-reported health outcomes in AS patients complicated by sleep disorders. The results emphasise the need for comprehensive care strategies that address the diverse needs and challenges faced by these patients and underscore the potential relevance of serum inflammatory factors, health index and disease activity scores as prognostic markers in this patient population.
摘要：
背景：强直性脊柱炎（AS）患者经常患有共病睡眠障碍，加重疾病负担，影响他们的生活质量。
目的：探讨血清炎症因子的临床意义，合并睡眠障碍的AS患者的健康指数和疾病活动评分。
方法：本研究共纳入106例合并睡眠障碍的AS患者。根据患者的临床结果，将患者分为理想和不良预后组。血清炎症因子水平,包括C反应蛋白,红细胞沉降率,白细胞介素（IL）-6，肿瘤坏死因子-α和IL-1β，被测量。疾病活动评分,如浴AS功能指数，巴斯AS疾病活动指数，BathAS计量学指数和AS疾病活动度评分，被评估。健康指数是通过简短表格36问卷获得的。
结果：该研究发现血清炎症因子之间存在显着关联，合并睡眠障碍的AS患者的健康指数和疾病活动评分。血清炎症因子与疾病活动度评分呈正相关,提示全身炎症对疾病严重程度和功能损害的影响。相反，疾病活动评分与健康指数参数呈负相关，强调疾病活动对健康相关生活质量各个方面的影响。Logistic回归分析进一步证实了这些因素对患者预后的预测价值，强调它们在风险评估和预测中的潜在效用。
结论：研究结果表明，疾病活动之间存在复杂的相互作用，合并睡眠障碍的AS患者的全身性炎症和患者报告的健康结局。结果强调需要全面的护理策略，以解决这些患者面临的不同需求和挑战，并强调血清炎症因子的潜在相关性。健康指数和疾病活动评分作为该患者人群的预后指标。
目的：探讨血清炎症因子的临床意义，合并睡眠障碍的AS患者的健康指数和疾病活动评分。
方法：本研究共纳入106例合并睡眠障碍的AS患者。根据患者的临床结果，将患者分为理想和不良预后组。血清炎症因子水平,包括C反应蛋白,红细胞沉降率,白细胞介素（IL）-6，肿瘤坏死因子-α和IL-1β，被测量。疾病活动评分,如浴AS功能指数，巴斯AS疾病活动指数，BathAS计量学指数和AS疾病活动度评分，被评估。健康指数是通过简短表格36问卷获得的。
结果：该研究发现血清炎症因子之间存在显着关联，合并睡眠障碍的AS患者的健康指数和疾病活动评分。血清炎症因子与疾病活动度评分呈正相关,提示全身炎症对疾病严重程度和功能损害的影响。相反，疾病活动评分与健康指数参数呈负相关，强调疾病活动对健康相关生活质量各个方面的影响。Logistic回归分析进一步证实了这些因素对患者预后的预测价值，强调它们在风险评估和预测中的潜在效用。
结论：研究结果表明，疾病活动之间存在复杂的相互作用，合并睡眠障碍的AS患者的全身性炎症和患者报告的健康结局。结果强调需要全面的护理策略，以解决这些患者面临的不同需求和挑战，并强调血清炎症因子的潜在相关性。健康指数和疾病活动评分作为该患者人群的预后指标。
