PDF(Pubmed)
Abstract：
Calcium plays a crucial role in the heart\'s electrical conduction system and facilitating the contraction of cardiac muscles. Hypocalcemia can result in electrocardiogram findings such as a prolonged QTC interval and eventually torsade de pointes, which in severe cases can progress to cardiac arrest. In cases of B-cell lymphoma, hypocalcemia may arise from various factors. Tumor infiltration can disrupt calcium homeostasis by affecting the parathyroid glands or bone tissue. Acidosis in the context of B-cell lymphoma can cause significant cardiovascular adverse effects. It will reduce peripheral vascular resistance and cardiac muscle contractility, promote dysrhythmias, and disturb oxygen uptake in the lungs. These combined effects markedly compromise cardiac function, increasing the likelihood of cardiac arrest. These mechanisms necessitate comprehensive management strategies in B-cell lymphoma patients. In this case report we present a case of cardiac arrest in a 59-year-old female woman with hypocalcemia and lactic acidosis secondary to B-cell lymphoma.
CONCLUSIONS: Lactic acidosis in B-cell lymphoma can be multifactorial. Contributing factors include inability of liver lactate clearance, tumor cell metabolism or impaired oxygenation.Patients with B-cell lymphoma may have hypocalcemia secondary to tumor lysis syndrome, paraneoplastic syndrome, or secondary to treatment.These reversible causes should always be considered in cardiac arrest in cancer patients.
CONCLUSIONS: Lactic acidosis in B-cell lymphoma can be multifactorial. Contributing factors include inability of liver lactate clearance, tumor cell metabolism or impaired oxygenation.Patients with B-cell lymphoma may have hypocalcemia secondary to tumor lysis syndrome, paraneoplastic syndrome, or secondary to treatment.These reversible causes should always be considered in cardiac arrest in cancer patients.
摘要：
钙在心脏的电传导系统和促进心肌收缩中起着至关重要的作用。低钙血症可导致心电图发现，如QTC间期延长，最终导致尖端扭转。在严重的情况下可以进展到心脏骤停。在B细胞淋巴瘤的情况下，低钙血症可能由多种因素引起。肿瘤浸润可以通过影响甲状旁腺或骨组织来破坏钙稳态。在B细胞淋巴瘤的背景下酸中毒可引起显著的心血管不良反应。它将降低外周血管阻力和心肌收缩力，促进心律失常，干扰肺部的氧气吸收。这些综合作用明显损害心脏功能，增加心脏骤停的可能性.这些机制需要B细胞淋巴瘤患者的综合管理策略。在此病例报告中，我们介绍了一例59岁女性心脏骤停的病例，该女性患有低钙血症和继发于B细胞淋巴瘤的乳酸性酸中毒。
结论：B细胞淋巴瘤中的乳酸性酸中毒可能是多因素的。促成因素包括不能清除肝脏乳酸，肿瘤细胞代谢或氧合受损。B细胞淋巴瘤患者可能有继发于肿瘤溶解综合征的低钙血症，副肿瘤综合征,或继发于治疗。在癌症患者的心脏骤停中，应始终考虑这些可逆原因。
结论：B细胞淋巴瘤中的乳酸性酸中毒可能是多因素的。促成因素包括不能清除肝脏乳酸，肿瘤细胞代谢或氧合受损。B细胞淋巴瘤患者可能有继发于肿瘤溶解综合征的低钙血症，副肿瘤综合征,或继发于治疗。在癌症患者的心脏骤停中，应始终考虑这些可逆原因。
