PDF(Pubmed)
Abstract：
UNASSIGNED: Approximately 85% of patients with thyroid eye disease experience ocular surface symptoms. Although corneal exposure plays a role in inducing inflammatory changes to the ocular surface, multiple studies reveal more complexity to the abnormal tear film composition and parameters in thyroid eye disease patients including those who do not have proptosis or increased corneal exposure. Currently, a majority of cases of thyroid associated dry eye symptoms are given treatments intended for ocular surface disease arising from different etiologies.
UNASSIGNED: Medline via Ovid, Cochrane CENTRAL, PubMed, and Google Scholar were systematically searched for articles evaluating the efficacy of treatments for dry eye symptoms in patients with thyroid eye disease. Articles were from all geographic regions and dates ranged from inception until October 2023.
UNASSIGNED: Seven papers ultimately met inclusion criteria and were included in this review. These papers revealed that multiple topical and non-topical treatment modalities address dry eye symptoms in thyroid eye disease and improve subjective and objective ocular surface parameters. However, due to the few studies that exist and due to disparities in sample size and study design, no overwhelming best practices were identified that could influence clinical practice.
UNASSIGNED: This systematic review identifies the current treatments that exist and highlights the clear unmet need for a large population suffering with dry eye symptoms. Ideally, further well-designed investigations into this area would target topical, non-invasive modalities to develop first line options for thyroid eye disease patients.
UNASSIGNED: Medline via Ovid, Cochrane CENTRAL, PubMed, and Google Scholar were systematically searched for articles evaluating the efficacy of treatments for dry eye symptoms in patients with thyroid eye disease. Articles were from all geographic regions and dates ranged from inception until October 2023.
UNASSIGNED: Seven papers ultimately met inclusion criteria and were included in this review. These papers revealed that multiple topical and non-topical treatment modalities address dry eye symptoms in thyroid eye disease and improve subjective and objective ocular surface parameters. However, due to the few studies that exist and due to disparities in sample size and study design, no overwhelming best practices were identified that could influence clinical practice.
UNASSIGNED: This systematic review identifies the current treatments that exist and highlights the clear unmet need for a large population suffering with dry eye symptoms. Ideally, further well-designed investigations into this area would target topical, non-invasive modalities to develop first line options for thyroid eye disease patients.
摘要：
■大约85%的甲状腺眼病患者出现眼表症状。尽管角膜暴露在诱导眼表炎症变化中起作用，多项研究揭示了甲状腺眼病患者,包括没有眼球突出或角膜暴露增加的患者,泪膜成分和参数异常更加复杂.目前,大多数甲状腺相关干眼症的病例都接受了针对不同病因引起的眼表疾病的治疗。
■MedlineviaOvid,科克伦中部,PubMed,和GoogleScholar进行了系统搜索，以评估甲状腺眼病患者干眼症状治疗效果的文章。文章来自所有地理区域，日期从开始到2023年10月。
■七篇论文最终符合纳入标准，并被纳入本综述。这些论文揭示了多种局部和非局部治疗方式解决了甲状腺眼病中的干眼症状，并改善了主观和客观的眼表参数。然而,由于存在的研究很少，并且由于样本量和研究设计的差异，没有发现可能影响临床实践的压倒性最佳实践.
■本系统综述确定了目前存在的治疗方法，并强调了对患有干眼症的大量人群的明显未满足的需求。理想情况下,对这一领域的进一步精心设计的调查将针对局部，非侵入性方式为甲状腺眼病患者开发一线选择。
■MedlineviaOvid,科克伦中部,PubMed,和GoogleScholar进行了系统搜索，以评估甲状腺眼病患者干眼症状治疗效果的文章。文章来自所有地理区域，日期从开始到2023年10月。
■七篇论文最终符合纳入标准，并被纳入本综述。这些论文揭示了多种局部和非局部治疗方式解决了甲状腺眼病中的干眼症状，并改善了主观和客观的眼表参数。然而,由于存在的研究很少，并且由于样本量和研究设计的差异，没有发现可能影响临床实践的压倒性最佳实践.
■本系统综述确定了目前存在的治疗方法，并强调了对患有干眼症的大量人群的明显未满足的需求。理想情况下,对这一领域的进一步精心设计的调查将针对局部，非侵入性方式为甲状腺眼病患者开发一线选择。
