PDF(Pubmed)
Abstract：
In recent years, optoretinography has become an important functional imaging method for the retina, as light-evoked changes in the photoreceptors have been demonstrated for a large number of different OCT systems. Full-field swept-source optical coherence tomography (FF-SS-OCT) is particularly phase-stable, and it is currently the only technique sensitive enough to detect the smaller functional changes in the inner plexiform layer (IPL). However, the resolution of state-of-the art FF-SS-OCT systems is not high enough to distinguish individual photoreceptors. This makes it difficult to separate rods from cones. In this work, we circumvent this problem by separating the functional changes in rods and cones by their different temporal dynamics to the same light stimulus. For this purpose, a mathematical model was developed that represents the measured signals as a superposition of two impulse responses. The developed model describes the measured data under different imaging conditions very well and is able to analyze the sensitivity and temporal dynamics of the two photoreceptor types separately.
摘要：
近年来,视网膜光成像已成为一种重要的视网膜功能成像方法,因为光诱发的光感受器的变化已被大量不同的OCT系统证实。全场扫频源光学相干层析成像(FF-SS-OCT)相位特别稳定,它是目前唯一足够灵敏的技术来检测内部丛状层（IPL）中的较小功能变化。然而,现有技术的FF-SS-OCT系统的分辨率不足以区分单个光感受器。这使得难以将杆与锥体分离。在这项工作中,我们通过将视杆和视锥的功能变化与相同的光刺激不同的时间动力学分离来规避这个问题。为此,建立了一个数学模型，将测量信号表示为两个脉冲响应的叠加。所开发的模型很好地描述了不同成像条件下的测量数据，并且能够分别分析两种感光体类型的灵敏度和时间动态。
