PDF(Pubmed)
Abstract：
UNASSIGNED: The paper was to investigate the clinical relevance of oxidative stress (OS) and inflammation-associated targets in coronary artery lesions (CALs) associated with Kawasaki disease (KD).
UNASSIGNED: The clinical data from 455 sufferers diagnosed with KD between February 2021 and June 2023 were gathered and divided into two groups: CAL and NCAL. The regression analysis was conducted to search for independent covariates for CALs related to OS and inflammation. The predictive nomogram was structured according to these risk factors. The properties of the model were estimated using calibration and receiver operating characteristic curves.
UNASSIGNED: The levels of CRP, IL-6, PLT count, ESR, ox-HDL, MDA, and PLR were more elevated in CAL patients with KD; interestingly, HDL and superoxide dismutase (SOD) were low in the CAL group. Ascension of CRP, IL-6, ESR, ox-HDL, MDA, and PLR, and diminution of HDL and SOD were considered independent risk factors. The nomogram constructed using these factors demonstrated a satisfactory calibration degree and discriminatory power, with an area under the curve of 0.812. In the verification set, the area under the curve was found to be 0.799.
UNASSIGNED: The model was established according to 8 OS and inflammation-associated risk factors bound up with CALs in KD sufferers. It may be a usable approach for early diagnosis of CALs in KD.
UNASSIGNED: The clinical data from 455 sufferers diagnosed with KD between February 2021 and June 2023 were gathered and divided into two groups: CAL and NCAL. The regression analysis was conducted to search for independent covariates for CALs related to OS and inflammation. The predictive nomogram was structured according to these risk factors. The properties of the model were estimated using calibration and receiver operating characteristic curves.
UNASSIGNED: The levels of CRP, IL-6, PLT count, ESR, ox-HDL, MDA, and PLR were more elevated in CAL patients with KD; interestingly, HDL and superoxide dismutase (SOD) were low in the CAL group. Ascension of CRP, IL-6, ESR, ox-HDL, MDA, and PLR, and diminution of HDL and SOD were considered independent risk factors. The nomogram constructed using these factors demonstrated a satisfactory calibration degree and discriminatory power, with an area under the curve of 0.812. In the verification set, the area under the curve was found to be 0.799.
UNASSIGNED: The model was established according to 8 OS and inflammation-associated risk factors bound up with CALs in KD sufferers. It may be a usable approach for early diagnosis of CALs in KD.
摘要：
■本文旨在研究氧化应激（OS）和炎症相关靶标在川崎病（KD）相关冠状动脉病变（CAL）中的临床相关性。
■收集了2021年2月至2023年6月之间诊断为KD的455名患者的临床数据，并将其分为两组：CAL和NCAL。进行回归分析以搜索与OS和炎症相关的CAL的独立协变量。根据这些风险因素构建预测列线图。使用校准和接收器工作特性曲线估计模型的属性。
■CRP水平，IL-6,PLT计数,ESR,ox-HDL,MDA,在患有KD的CAL患者中，PLR升高；有趣的是，CAL组HDL和超氧化物歧化酶（SOD）较低。CRP的提升，IL-6,ESR,ox-HDL,MDA,和PLR,HDL和SOD的降低被认为是独立的危险因素。使用这些因素构建的列线图显示出令人满意的校准度和判别力，曲线下面积为0.812。在验证集中，曲线下面积为0.799.
■该模型是根据KD患者的8OS和与CAL相关的炎症相关危险因素建立的。这可能是KD中CAL早期诊断的有效方法。
■收集了2021年2月至2023年6月之间诊断为KD的455名患者的临床数据，并将其分为两组：CAL和NCAL。进行回归分析以搜索与OS和炎症相关的CAL的独立协变量。根据这些风险因素构建预测列线图。使用校准和接收器工作特性曲线估计模型的属性。
■CRP水平，IL-6,PLT计数,ESR,ox-HDL,MDA,在患有KD的CAL患者中，PLR升高；有趣的是，CAL组HDL和超氧化物歧化酶（SOD）较低。CRP的提升，IL-6,ESR,ox-HDL,MDA,和PLR,HDL和SOD的降低被认为是独立的危险因素。使用这些因素构建的列线图显示出令人满意的校准度和判别力，曲线下面积为0.812。在验证集中，曲线下面积为0.799.
■该模型是根据KD患者的8OS和与CAL相关的炎症相关危险因素建立的。这可能是KD中CAL早期诊断的有效方法。
