PDF(Pubmed)
Abstract：
Selectins are cell adhesion proteins discovered in the 1980s. As C-type lectins, selectins contain an essential calcium ion in the ligand-binding pocket and recognize the isomeric tetrasaccharides sialyl Lewisx (sLex) and sialyl Lewisa (sLea). Three selectins, E-selectin, P-selectin, and L-selectin, play distinct, complementary roles in inflammation, hematopoiesis, and tumor biology. They have been implicated in the pathology of diverse inflammatory disorders, and several selectin antagonists have been tested clinically. E-selectin plays a unique role in leukocyte activation, making it an attractive target for intervention, for example, in sickle cell disease (SCD). This review summarizes selectin biology and pathology, structure and ligand binding, and selectin antagonists that have reached clinical testing with an emphasis on E-selectin.
摘要：
选择蛋白是1980年代发现的细胞粘附蛋白。作为C型凝集素，选择素在配体结合袋中含有必需的钙离子，并识别异构体四糖唾液酸Lewisx（sLex）和唾液酸Lewisa（sLea）。三个选择，E-选择素,P-选择素,和L-选择素，发挥独特，在炎症中的互补作用，造血,和肿瘤生物学。它们与各种炎症性疾病的病理学有关，和几种选择素拮抗剂已经进行了临床测试。E-选择素在白细胞活化中起着独特的作用,使其成为有吸引力的干预目标，例如,镰状细胞病（SCD）。本文综述了选择素的生物学和病理学，结构和配体结合，和选择素拮抗剂已经达到临床试验，重点是E-选择素。
