UNASSIGNED: We retrospectively studied AxL changes in children with PCG undergoing surgery. Eyes of children aged ≤ 4 years that did not have prior ocular surgery and that underwent at least one glaucoma surgery during the course of follow-up between June 2014 and July 2018, were included. The effect of change in IOP on change in AxL was estimated using linear mixed effects models.
UNASSIGNED: A total of 105 eyes (of 72 children) with PCG underwent glaucoma surgery representing 26.4% (105/397) eyes. The mean ± SD age of children at baseline was 3.53 ± 4.04 months. At baseline, the mean IOP and AxL were 26.63 ± 9.57 mmHg and 21.67 ± 1.82 mm, respectively. During the course of follow-up post-surgery, the IOP decreased by a mean of 7.25 ± 12.08 mmHg while the AxL increased by a mean of 0.70 ± 1.40 mm. A multivariable mixed effects linear regression revealed that change in AxL was significantly associated with change in IOP (p=0.030) and time since first surgery (p<0.001). A substantial reduction in IOP (≥35 mmHg) was needed at 3 months post-surgery, for AxL to regress.
UNASSIGNED: In children with PCG who undergo glaucoma surgery, change in IOP significantly influences change in AxL. For AxL to regress, a substantial reduction in IOP is needed post-surgery.
■我们回顾性研究了接受手术的PCG患儿的AxL变化。纳入了在2014年6月至2018年7月期间随访期间未接受过眼科手术且至少接受过一次青光眼手术的≤4岁儿童的眼睛。使用线性混合效应模型估计IOP变化对AxL变化的影响。
■共有105只眼(72例儿童)的PCG患者接受了青光眼手术,占26.4%(105/397)的眼睛。基线儿童的平均±SD年龄为3.53±4.04个月。在基线,平均眼压和AxL分别为26.63±9.57mmHg和21.67±1.82mm,分别。在手术后的随访过程中,眼压平均下降7.25±12.08mmHg,AxL平均上升0.70±1.40mm。多变量混合效应线性回归显示,AxL的变化与IOP的变化(p=0.030)和首次手术后的时间(p<0.001)显着相关。术后3个月需要大幅降低IOP(≥35mmHg),让AxL回归。
■在接受青光眼手术的PCG儿童中,眼压的变化显著影响AxL的变化。为了让AxL回归,手术后需要大幅降低IOP.