PDF(Pubmed)
Abstract：
UNASSIGNED: Primary congenital glaucoma (PCG) is a challenging condition to diagnose, treat and effectively monitor. Serial assessment of intraocular pressure (IOP), optic disc cupping, refraction, and axial length (AxL) after surgery are useful to assess disease control. This study aimed to evaluate AxL changes in relation to IOP changes following glaucoma surgery in children with PCG.
UNASSIGNED: We retrospectively studied AxL changes in children with PCG undergoing surgery. Eyes of children aged ≤ 4 years that did not have prior ocular surgery and that underwent at least one glaucoma surgery during the course of follow-up between June 2014 and July 2018, were included. The effect of change in IOP on change in AxL was estimated using linear mixed effects models.
UNASSIGNED: A total of 105 eyes (of 72 children) with PCG underwent glaucoma surgery representing 26.4% (105/397) eyes. The mean ± SD age of children at baseline was 3.53 ± 4.04 months. At baseline, the mean IOP and AxL were 26.63 ± 9.57 mmHg and 21.67 ± 1.82 mm, respectively. During the course of follow-up post-surgery, the IOP decreased by a mean of 7.25 ± 12.08 mmHg while the AxL increased by a mean of 0.70 ± 1.40 mm. A multivariable mixed effects linear regression revealed that change in AxL was significantly associated with change in IOP (p=0.030) and time since first surgery (p<0.001). A substantial reduction in IOP (≥35 mmHg) was needed at 3 months post-surgery, for AxL to regress.
UNASSIGNED: In children with PCG who undergo glaucoma surgery, change in IOP significantly influences change in AxL. For AxL to regress, a substantial reduction in IOP is needed post-surgery.
UNASSIGNED: We retrospectively studied AxL changes in children with PCG undergoing surgery. Eyes of children aged ≤ 4 years that did not have prior ocular surgery and that underwent at least one glaucoma surgery during the course of follow-up between June 2014 and July 2018, were included. The effect of change in IOP on change in AxL was estimated using linear mixed effects models.
UNASSIGNED: A total of 105 eyes (of 72 children) with PCG underwent glaucoma surgery representing 26.4% (105/397) eyes. The mean ± SD age of children at baseline was 3.53 ± 4.04 months. At baseline, the mean IOP and AxL were 26.63 ± 9.57 mmHg and 21.67 ± 1.82 mm, respectively. During the course of follow-up post-surgery, the IOP decreased by a mean of 7.25 ± 12.08 mmHg while the AxL increased by a mean of 0.70 ± 1.40 mm. A multivariable mixed effects linear regression revealed that change in AxL was significantly associated with change in IOP (p=0.030) and time since first surgery (p<0.001). A substantial reduction in IOP (≥35 mmHg) was needed at 3 months post-surgery, for AxL to regress.
UNASSIGNED: In children with PCG who undergo glaucoma surgery, change in IOP significantly influences change in AxL. For AxL to regress, a substantial reduction in IOP is needed post-surgery.
摘要：
■原发性先天性青光眼（PCG）是一种具有挑战性的诊断条件，治疗和有效监测。眼内压（IOP）的系列评估，视神经盘拔罐，折射,手术后的轴向长度（AxL）可用于评估疾病控制。这项研究旨在评估PCG患儿青光眼手术后AxL变化与IOP变化的关系。
■我们回顾性研究了接受手术的PCG患儿的AxL变化。纳入了在2014年6月至2018年7月期间随访期间未接受过眼科手术且至少接受过一次青光眼手术的≤4岁儿童的眼睛。使用线性混合效应模型估计IOP变化对AxL变化的影响。
■共有105只眼（72例儿童）的PCG患者接受了青光眼手术，占26.4%（105/397）的眼睛。基线儿童的平均±SD年龄为3.53±4.04个月。在基线,平均眼压和AxL分别为26.63±9.57mmHg和21.67±1.82mm，分别。在手术后的随访过程中，眼压平均下降7.25±12.08mmHg,AxL平均上升0.70±1.40mm。多变量混合效应线性回归显示，AxL的变化与IOP的变化（p=0.030）和首次手术后的时间（p<0.001）显着相关。术后3个月需要大幅降低IOP（≥35mmHg），让AxL回归。
■在接受青光眼手术的PCG儿童中，眼压的变化显著影响AxL的变化。为了让AxL回归，手术后需要大幅降低IOP.
■我们回顾性研究了接受手术的PCG患儿的AxL变化。纳入了在2014年6月至2018年7月期间随访期间未接受过眼科手术且至少接受过一次青光眼手术的≤4岁儿童的眼睛。使用线性混合效应模型估计IOP变化对AxL变化的影响。
■共有105只眼（72例儿童）的PCG患者接受了青光眼手术，占26.4%（105/397）的眼睛。基线儿童的平均±SD年龄为3.53±4.04个月。在基线,平均眼压和AxL分别为26.63±9.57mmHg和21.67±1.82mm，分别。在手术后的随访过程中，眼压平均下降7.25±12.08mmHg,AxL平均上升0.70±1.40mm。多变量混合效应线性回归显示，AxL的变化与IOP的变化（p=0.030）和首次手术后的时间（p<0.001）显着相关。术后3个月需要大幅降低IOP（≥35mmHg），让AxL回归。
■在接受青光眼手术的PCG儿童中，眼压的变化显著影响AxL的变化。为了让AxL回归，手术后需要大幅降低IOP.
