PDF(Pubmed)
Abstract：
Over the past two decades, there has been tremendous and exciting progress toward extending the use of medical ultrasound beyond a traditional imaging tool. Ultrasound contrast agents, typically used for improved visualization of blood flow, have been explored as novel non-viral gene delivery vectors for cardiovascular therapy. Given this adaptation to ultrasound contrast-enhancing agents, this presents as an image-guided and site-specific gene delivery technique with potential for multi-gene and repeatable delivery protocols-overcoming some of the limitations of alternative gene therapy approaches. In this review, we provide an overview of the studies to date that employ this technique toward cardiac gene therapy using cardiovascular disease animal models and summarize their key findings.
摘要：
在过去的二十年里，在将医疗超声的使用范围扩展到传统的成像工具之外，已经取得了巨大而令人兴奋的进展。超声造影剂,通常用于改善血流的可视化，已经被探索作为用于心血管治疗的新型非病毒基因递送载体。鉴于这种对超声造影增强剂的适应性，这是一种图像引导和位点特异性基因递送技术,具有多基因和可重复递送方案的潜力-克服了替代基因治疗方法的一些局限性.在这次审查中,我们概述了迄今为止使用心血管疾病动物模型将该技术用于心脏基因治疗的研究,并总结了其主要发现.
