PDF(Pubmed)
Abstract：
Renal epithelial-to-mesenchymal transition (EMT) is a process in which epithelial cells undergo biochemical changes and transform into mesenchymal-like cells, resulting in renal abnormalities, including fibrosis. EMT can cause diabetic nephropathy through triggering kidney fibrosis, inflammation, and functional impairment. The diverse molecular pathways that drive EMT-mediated renal fibrosis are not utterly known. Targeting key signaling pathways involved in EMT may help ameliorate diabetic nephropathy and improve renal function. In such settings, understanding precisely the complicated signaling networks is critical for developing customized therapies to intervene in EMT-mediated diabetic nephropathy.
摘要：
肾上皮间质转化(EMT)是上皮细胞发生生化改变并转化为间充质样细胞的过程,导致肾脏异常，包括纤维化。EMT可通过引发肾纤维化引起糖尿病肾病,炎症,和功能损害。驱动EMT介导的肾纤维化的多种分子途径尚不完全清楚。靶向参与EMT的关键信号通路可能有助于改善糖尿病肾病和改善肾功能。在这样的设置中，准确了解复杂的信号传导网络对于开发干预EMT介导的糖尿病肾病的定制疗法至关重要.
