PDF(Pubmed)
Abstract：
UNASSIGNED: Fibroblast growth factor 21 (FGF21) is a stress-inducible hormone that regulates nutrient and metabolic homeostasis. Inflammatory state is one of the stimulators of FGF21 secretion. The aim of the study was to assess correlations between serum FGF21 level and inflammatory markers as well as nutritional status indicators in patients with inflammatory bowel disease (IBD).
UNASSIGNED: Fasting serum FGF21 level was measured using ELISA test in 105 IBD patients and 17 healthy controls. There were 31 subjects with active ulcerative colitis (UC), 16 with inactive UC, 36 with active Crohn\'s disease (CD), and 22 with inactive CD. Clinical and endoscopic activity of IBD was evaluated based on validated scales and indices. Fecal calprotectin, serum CRP, and selected parameters of nutritional status were tested in all patients.
UNASSIGNED: Serum FGF21 level was characterized by fluctuations depending on the IBD activity. FGF21 level was significantly higher in both active UC and CD compared to inactive phases of the diseases and to the controls. A correlation between FGF21 and fecal calprotectin levels was also found in UC and CD. Additionally, in CD, FGF21 level positively correlated with CRP level. In both UC and CD, a negative correlation was noted between FGF21 level and nutritional status parameters including cholesterol, protein, albumin levels, and BMI.
UNASSIGNED: The intensity of intestinal inflammation is related to FGF21 level, which correlates negatively with nutritional status indicators in IBD. The disturbances in FGF21 secretion may contribute to the multifactorial pathogenesis of malnutrition and weight loss in IBD patients.
UNASSIGNED: Fasting serum FGF21 level was measured using ELISA test in 105 IBD patients and 17 healthy controls. There were 31 subjects with active ulcerative colitis (UC), 16 with inactive UC, 36 with active Crohn\'s disease (CD), and 22 with inactive CD. Clinical and endoscopic activity of IBD was evaluated based on validated scales and indices. Fecal calprotectin, serum CRP, and selected parameters of nutritional status were tested in all patients.
UNASSIGNED: Serum FGF21 level was characterized by fluctuations depending on the IBD activity. FGF21 level was significantly higher in both active UC and CD compared to inactive phases of the diseases and to the controls. A correlation between FGF21 and fecal calprotectin levels was also found in UC and CD. Additionally, in CD, FGF21 level positively correlated with CRP level. In both UC and CD, a negative correlation was noted between FGF21 level and nutritional status parameters including cholesterol, protein, albumin levels, and BMI.
UNASSIGNED: The intensity of intestinal inflammation is related to FGF21 level, which correlates negatively with nutritional status indicators in IBD. The disturbances in FGF21 secretion may contribute to the multifactorial pathogenesis of malnutrition and weight loss in IBD patients.
摘要：
■成纤维细胞生长因子21（FGF21）是一种应激诱导激素，可调节营养和代谢稳态。炎症状态是FGF21分泌的刺激物之一。该研究的目的是评估炎症性肠病（IBD）患者血清FGF21水平与炎症标志物以及营养状况指标之间的相关性。
■使用ELISA测试在105名IBD患者和17名健康对照中测量空腹血清FGF21水平。有31名受试者患有活动性溃疡性结肠炎（UC），16不活动的UC，36患有活动性克罗恩病（CD），和22不活动CD。根据经过验证的量表和指标评估IBD的临床和内镜活动。粪便钙卫蛋白,血清CRP,并对所有患者的营养状态参数进行了测试。
■血清FGF21水平的特征在于取决于IBD活性的波动。与疾病的非活动阶段和对照相比，活动性UC和CD中的FGF21水平均显着较高。在UC和CD中也发现了FGF21和粪便钙卫蛋白水平之间的相关性。此外,在CD中,FGF21水平与CRP水平呈正相关。在UC和CD中，FGF21水平与包括胆固醇在内的营养状况参数呈负相关，蛋白质，白蛋白水平，BMI。
■肠道炎症的强度与FGF21水平有关，这与IBD的营养状况指标呈负相关。FGF21分泌的紊乱可能导致IBD患者营养不良和体重减轻的多因素发病机制。
■使用ELISA测试在105名IBD患者和17名健康对照中测量空腹血清FGF21水平。有31名受试者患有活动性溃疡性结肠炎（UC），16不活动的UC，36患有活动性克罗恩病（CD），和22不活动CD。根据经过验证的量表和指标评估IBD的临床和内镜活动。粪便钙卫蛋白,血清CRP,并对所有患者的营养状态参数进行了测试。
■血清FGF21水平的特征在于取决于IBD活性的波动。与疾病的非活动阶段和对照相比，活动性UC和CD中的FGF21水平均显着较高。在UC和CD中也发现了FGF21和粪便钙卫蛋白水平之间的相关性。此外,在CD中,FGF21水平与CRP水平呈正相关。在UC和CD中，FGF21水平与包括胆固醇在内的营养状况参数呈负相关，蛋白质，白蛋白水平，BMI。
■肠道炎症的强度与FGF21水平有关，这与IBD的营养状况指标呈负相关。FGF21分泌的紊乱可能导致IBD患者营养不良和体重减轻的多因素发病机制。
