PDF(Pubmed)
Abstract：
UNASSIGNED: Chagas disease (CD) is a neglected tropical disease from the American continent that commonly causes cardiovascular disease. Some patients develop neurological manifestations. We discuss and summarize the pathogenesis, clinical characteristics, diagnosis, and treatment of the central nervous system manifestations of CD.
UNASSIGNED: Cerebrospinal fluid quantitative polymerase chain reaction tests and next-generation sequencing in tissue samples have facilitated disease diagnosis and follow-up. Novel presentations, including retinitis, are now reported. A new MRI sign called \"Bunch of açai berries appearance\"-multiple hypointense nodular lesions-has been described recently. Treatment with benznidazole at higher doses and the role of therapeutic drug monitoring need to be further studied in this setting.
UNASSIGNED: A high suspicion index is paramount to diagnosing Chagas\' central nervous system involvement. Standardized molecular diagnostics can aid in the initial workup. Future development of new therapeutic drugs is crucial because of the toxicity profile of the currently available medications.
UNASSIGNED: Cerebrospinal fluid quantitative polymerase chain reaction tests and next-generation sequencing in tissue samples have facilitated disease diagnosis and follow-up. Novel presentations, including retinitis, are now reported. A new MRI sign called \"Bunch of açai berries appearance\"-multiple hypointense nodular lesions-has been described recently. Treatment with benznidazole at higher doses and the role of therapeutic drug monitoring need to be further studied in this setting.
UNASSIGNED: A high suspicion index is paramount to diagnosing Chagas\' central nervous system involvement. Standardized molecular diagnostics can aid in the initial workup. Future development of new therapeutic drugs is crucial because of the toxicity profile of the currently available medications.
摘要：
■恰加斯病（CD）是一种来自美洲大陆的被忽视的热带病，通常会导致心血管疾病。一些患者出现神经系统表现。我们讨论和总结了发病机制，临床特征,诊断,和治疗CD的中枢神经系统表现。
■脑脊液定量聚合酶链反应测试和组织样本的下一代测序有助于疾病诊断和随访。新颖的介绍，包括视网膜炎,现在有报道。最近描述了一种新的MRI征象，称为“阿萨伊浆果群外观”-多个低信号结节病变。在这种情况下，需要进一步研究高剂量苯并咪唑的治疗以及治疗药物监测的作用。
■高度怀疑指数对于诊断查加斯中枢神经系统受累至关重要。标准化的分子诊断可以帮助最初的工作。由于当前可用药物的毒性特征，新治疗药物的未来开发至关重要。
■脑脊液定量聚合酶链反应测试和组织样本的下一代测序有助于疾病诊断和随访。新颖的介绍，包括视网膜炎,现在有报道。最近描述了一种新的MRI征象，称为“阿萨伊浆果群外观”-多个低信号结节病变。在这种情况下，需要进一步研究高剂量苯并咪唑的治疗以及治疗药物监测的作用。
■高度怀疑指数对于诊断查加斯中枢神经系统受累至关重要。标准化的分子诊断可以帮助最初的工作。由于当前可用药物的毒性特征，新治疗药物的未来开发至关重要。
