PDF(Pubmed)
Abstract：
BACKGROUND: Electronic cigarettes (ECs) have been promoted as alternatives to traditional cigarettes.
OBJECTIVE: To investigate ECs\' effects on respiratory system, especially in patients with respiratory diseases.
METHODS: We randomly selected 25 smokers with stable moderate asthma and matched them with 25 healthy smokers. All were subjucted to pulmonary function tests (PFTs), impulse oscillometry (IOS), fraction exhaled Nitric Oxide (FeNO), exhaled breathe condensate (EBC) and biomarker measurements before and after vaping one nicotine-containing EC.
RESULTS: The increase in FeNO 30 minutes after EC, reflecting airway inflammation, significantly correlated with increase of residual volume (RV), total lung capacity, respiratory impedance at 5 Hz (Z5Hz) and respiratory resistance at 5 and 20 Hz (R5Hz and R20Hz). No significant correlations were found between EBC biomarkers\' changes and respiratory mechanics.
CONCLUSIONS: This is the first study demonstrating that the changes in airway inflammation caused by EC have direct effects in respiratory mechanics of asthmatic patients.
OBJECTIVE: To investigate ECs\' effects on respiratory system, especially in patients with respiratory diseases.
METHODS: We randomly selected 25 smokers with stable moderate asthma and matched them with 25 healthy smokers. All were subjucted to pulmonary function tests (PFTs), impulse oscillometry (IOS), fraction exhaled Nitric Oxide (FeNO), exhaled breathe condensate (EBC) and biomarker measurements before and after vaping one nicotine-containing EC.
RESULTS: The increase in FeNO 30 minutes after EC, reflecting airway inflammation, significantly correlated with increase of residual volume (RV), total lung capacity, respiratory impedance at 5 Hz (Z5Hz) and respiratory resistance at 5 and 20 Hz (R5Hz and R20Hz). No significant correlations were found between EBC biomarkers\' changes and respiratory mechanics.
CONCLUSIONS: This is the first study demonstrating that the changes in airway inflammation caused by EC have direct effects in respiratory mechanics of asthmatic patients.
摘要：
背景：电子香烟（EC）已被推广为传统香烟的替代品。
目的：为了研究ECs对呼吸系统的影响，尤其是呼吸道疾病患者。
方法：我们随机选择25名中度哮喘稳定期吸烟者，并与25名健康吸烟者进行匹配。所有患者均接受肺功能检查（PFTs），脉冲振荡法(IOS)，呼出气一氧化氮（FeNO），吸一种含尼古丁的EC之前和之后的呼出呼吸冷凝液（EBC）和生物标志物测量。
结果：EC30分钟后FeNO的增加，反映气道炎症，与剩余体积（RV）的增加显着相关，肺总容量,5Hz时的呼吸阻抗（Z5Hz）和5和20Hz时的呼吸阻抗（R5Hz和R20Hz）。在EBC生物标志物的变化和呼吸力学之间没有发现显著的相关性。
结论：这是第一项研究，证明EC引起的气道炎症变化对哮喘患者的呼吸力学有直接影响。
目的：为了研究ECs对呼吸系统的影响，尤其是呼吸道疾病患者。
方法：我们随机选择25名中度哮喘稳定期吸烟者，并与25名健康吸烟者进行匹配。所有患者均接受肺功能检查（PFTs），脉冲振荡法(IOS)，呼出气一氧化氮（FeNO），吸一种含尼古丁的EC之前和之后的呼出呼吸冷凝液（EBC）和生物标志物测量。
结果：EC30分钟后FeNO的增加，反映气道炎症，与剩余体积（RV）的增加显着相关，肺总容量,5Hz时的呼吸阻抗（Z5Hz）和5和20Hz时的呼吸阻抗（R5Hz和R20Hz）。在EBC生物标志物的变化和呼吸力学之间没有发现显著的相关性。
结论：这是第一项研究，证明EC引起的气道炎症变化对哮喘患者的呼吸力学有直接影响。
