PDF(Pubmed)
Abstract：
UNASSIGNED: General and abdominal obesity are prevalent, with established associations to frailty in the elderly. However, few studies have investigated these associations in patients with chronic kidney disease (CKD), yielding inconsistent results.
UNASSIGNED: This cross-sectional study analysed data from the National Health and Nutrition Examination Survey (NHANES 2003-2018). Frailty was evaluated by the 36-item frailty index. General obesity was defined as a body mass index (BMI) >30 kg/m2; abdominal obesity was identified if waist circumference (WC) reached 102 cm in men and 88 cm in women. The associations of general and abdominal obesity with frailty were analysed using weighted multivariate logistic regression and restricted cubic splines. The interaction of general and abdominal obesity with frailty was examined.
UNASSIGNED: A total of 5604 adult patients (median age 71 years, 42% men) with CKD were included in this analysis, with a median estimated glomerular filtration rate of 57.3 ml/min/1.73 m2. A total of 21% were frail with general obesity and 32% were frail with abdominal obesity. Neither general nor abdominal obesity alone was associated with frailty. There was an interaction between general and abdominal obesity with frailty. Compared with individuals with normal BMI and WC, those with both general and abdominal obesity, rather than either alone, exhibited significantly increased odds of frailty {odds ratio [OR] 1.53 [95% confidence interval (CI) 1.20-1.95]}. General obesity was associated with being frail only when CKD patients had abdominal obesity [OR 1.59 (95% CI 1.08-2.36)].
UNASSIGNED: There may be an interaction between general and abdominal obesity with frailty in patients with CKD. Interventions aimed at preventing frailty should consider both aspects.
UNASSIGNED: This cross-sectional study analysed data from the National Health and Nutrition Examination Survey (NHANES 2003-2018). Frailty was evaluated by the 36-item frailty index. General obesity was defined as a body mass index (BMI) >30 kg/m2; abdominal obesity was identified if waist circumference (WC) reached 102 cm in men and 88 cm in women. The associations of general and abdominal obesity with frailty were analysed using weighted multivariate logistic regression and restricted cubic splines. The interaction of general and abdominal obesity with frailty was examined.
UNASSIGNED: A total of 5604 adult patients (median age 71 years, 42% men) with CKD were included in this analysis, with a median estimated glomerular filtration rate of 57.3 ml/min/1.73 m2. A total of 21% were frail with general obesity and 32% were frail with abdominal obesity. Neither general nor abdominal obesity alone was associated with frailty. There was an interaction between general and abdominal obesity with frailty. Compared with individuals with normal BMI and WC, those with both general and abdominal obesity, rather than either alone, exhibited significantly increased odds of frailty {odds ratio [OR] 1.53 [95% confidence interval (CI) 1.20-1.95]}. General obesity was associated with being frail only when CKD patients had abdominal obesity [OR 1.59 (95% CI 1.08-2.36)].
UNASSIGNED: There may be an interaction between general and abdominal obesity with frailty in patients with CKD. Interventions aimed at preventing frailty should consider both aspects.
摘要：
■一般和腹部肥胖很普遍，与老年人虚弱的既定协会。然而,很少有研究调查慢性肾脏病（CKD）患者的这些关联，产生不一致的结果。
■这项横断面研究分析了国家健康和营养调查（NHANES2003-2018）的数据。通过36项虚弱指数评估虚弱。一般肥胖定义为体重指数（BMI）>30kg/m2；如果男性腰围（WC）达到102cm，女性达到88cm，则确定为腹部肥胖。使用加权多变量逻辑回归和限制性三次样条分析了一般肥胖和腹部肥胖与虚弱的关联。检查了一般肥胖和腹部肥胖与虚弱的相互作用。
■共有5604名成年患者（平均年龄71岁，42%的男性)CKD患者被纳入本分析，估计肾小球滤过率中位数为57.3ml/min/1.73m2。共有21％的人患有普通肥胖症，而32％的人患有腹部肥胖症。单纯的全身肥胖和腹部肥胖都与虚弱无关。全身肥胖和腹部肥胖与虚弱之间存在相互作用。与BMI和WC正常的个体相比，一般和腹部肥胖的人，而不是一个人，表现出虚弱的几率显著增加{优势比[OR]1.53[95%置信区间(CI)1.20-1.95]}。一般肥胖仅在CKD患者患有腹部肥胖时与虚弱相关[OR1.59(95%CI1.08-2.36)]。
■CKD患者的全身肥胖和腹部肥胖与虚弱之间可能存在相互作用。旨在防止虚弱的干预措施应考虑这两个方面。
■这项横断面研究分析了国家健康和营养调查（NHANES2003-2018）的数据。通过36项虚弱指数评估虚弱。一般肥胖定义为体重指数（BMI）>30kg/m2；如果男性腰围（WC）达到102cm，女性达到88cm，则确定为腹部肥胖。使用加权多变量逻辑回归和限制性三次样条分析了一般肥胖和腹部肥胖与虚弱的关联。检查了一般肥胖和腹部肥胖与虚弱的相互作用。
■共有5604名成年患者（平均年龄71岁，42%的男性)CKD患者被纳入本分析，估计肾小球滤过率中位数为57.3ml/min/1.73m2。共有21％的人患有普通肥胖症，而32％的人患有腹部肥胖症。单纯的全身肥胖和腹部肥胖都与虚弱无关。全身肥胖和腹部肥胖与虚弱之间存在相互作用。与BMI和WC正常的个体相比，一般和腹部肥胖的人，而不是一个人，表现出虚弱的几率显著增加{优势比[OR]1.53[95%置信区间(CI)1.20-1.95]}。一般肥胖仅在CKD患者患有腹部肥胖时与虚弱相关[OR1.59(95%CI1.08-2.36)]。
■CKD患者的全身肥胖和腹部肥胖与虚弱之间可能存在相互作用。旨在防止虚弱的干预措施应考虑这两个方面。
