PDF(Pubmed)
Abstract：
UNASSIGNED: To analyze the choriocapillaris vessel density (CVD) of eyes at different stages of Age-related Macular Degeneration (AMD) with Optical Coherence Tomography Angiography (OCTA).
UNASSIGNED: This is a prospective observational cross-sectional study on 21 age-matched healthy eyes and 84 eyes with AMD (i.e., early AMD, late AMD, Geographic Atrophy [GA], and disciform scar AMD). OCTA was used to automatically measure the CVD (%), on both the whole macula and the foveal area, in a layer going from 9 µm above to 30 µm below the Bruch\'s membrane. Furthermore, in the GA subgroup, the extension of the Ellipsoid Zone (EZ) interruption and the area of macular chorio-retinal atrophy was analyzed.
UNASSIGNED: Macular CVD was significantly lower in the GA, late AMD and disciform scar AMD-subgroups compared to controls (respectively, p=0.0052; p<0.0001; p=0.0003), whereas it did not significantly vary in the early AMD group (p=0.86). A significant difference between the early AMD and both the late AMD and the disciform scar AMD subgroups was also found (p=0.0009 and 0.0095, respectively). When comparing the foveal CVD of healthy and AMD eyes, a significant difference was found with every AMD subgroup (early AMD, p=0.011; GA, p<0.0001; late AMD, p<0.0001; disciform scar AMD, p<0.0001). Furthermore, in the GA subgroup, the CVD had an inverse correlation with both the extension of the EZ-interruption (p=0.012) and with the calculated chorio-retinal atrophic area (p=0.009).
UNASSIGNED: OCTA could play a crucial role in the categorization of AMD, allowing for the evaluation of gradual flow impairment at different stages of the disease. Moreover, the detection of a decreased macular and foveal CVD may shed light on the pathogenesis of AMD.
UNASSIGNED: This is a prospective observational cross-sectional study on 21 age-matched healthy eyes and 84 eyes with AMD (i.e., early AMD, late AMD, Geographic Atrophy [GA], and disciform scar AMD). OCTA was used to automatically measure the CVD (%), on both the whole macula and the foveal area, in a layer going from 9 µm above to 30 µm below the Bruch\'s membrane. Furthermore, in the GA subgroup, the extension of the Ellipsoid Zone (EZ) interruption and the area of macular chorio-retinal atrophy was analyzed.
UNASSIGNED: Macular CVD was significantly lower in the GA, late AMD and disciform scar AMD-subgroups compared to controls (respectively, p=0.0052; p<0.0001; p=0.0003), whereas it did not significantly vary in the early AMD group (p=0.86). A significant difference between the early AMD and both the late AMD and the disciform scar AMD subgroups was also found (p=0.0009 and 0.0095, respectively). When comparing the foveal CVD of healthy and AMD eyes, a significant difference was found with every AMD subgroup (early AMD, p=0.011; GA, p<0.0001; late AMD, p<0.0001; disciform scar AMD, p<0.0001). Furthermore, in the GA subgroup, the CVD had an inverse correlation with both the extension of the EZ-interruption (p=0.012) and with the calculated chorio-retinal atrophic area (p=0.009).
UNASSIGNED: OCTA could play a crucial role in the categorization of AMD, allowing for the evaluation of gradual flow impairment at different stages of the disease. Moreover, the detection of a decreased macular and foveal CVD may shed light on the pathogenesis of AMD.
摘要：
■用光学相干断层扫描血管造影（OCTA）分析年龄相关性黄斑变性（AMD）不同阶段的眼脉络膜毛细血管密度（CVD）。
■这是一项针对21只年龄匹配的健康眼睛和84只患有AMD的眼睛的前瞻性观察性横断面研究（即，早期AMD,晚期AMD,地理萎缩[GA]，和盘状疤痕AMD）。OCTA用于自动测量CVD（%），在整个黄斑和中央凹区域，在布鲁赫膜上方9微米到下方30微米的一层中。此外，在GA子群中，分析了椭球区（EZ）中断的扩展和黄斑脉络膜视网膜萎缩的区域。
■在GA中，黄斑CVD明显较低，与对照组相比，晚期AMD和盘状瘢痕AMD亚组(分别，p=0.0052；p<0.0001；p=0.0003），而早期AMD组没有显着变化（p=0.86）。还发现了早期AMD与晚期AMD和盘状瘢痕AMD亚组之间的显着差异（分别为p=0.0009和0.0095）。比较健康眼睛和AMD眼睛的中央凹CVD时，发现每个AMD亚组存在显着差异(早期AMD，p=0.011;GA,p<0.0001；晚期AMD，p<0.0001；盘状瘢痕AMD，p<0.0001)。此外，在GA子群中，CVD与EZ中断的延长(p=0.012)和计算的脉络膜视网膜萎缩面积(p=0.009)均呈负相关.
■OCTA可能在AMD的分类中起关键作用，允许评估疾病不同阶段的逐渐流量损害。此外，黄斑和中央凹CVD降低的检测可能有助于揭示AMD的发病机制.
■这是一项针对21只年龄匹配的健康眼睛和84只患有AMD的眼睛的前瞻性观察性横断面研究（即，早期AMD,晚期AMD,地理萎缩[GA]，和盘状疤痕AMD）。OCTA用于自动测量CVD（%），在整个黄斑和中央凹区域，在布鲁赫膜上方9微米到下方30微米的一层中。此外，在GA子群中，分析了椭球区（EZ）中断的扩展和黄斑脉络膜视网膜萎缩的区域。
■在GA中，黄斑CVD明显较低，与对照组相比，晚期AMD和盘状瘢痕AMD亚组(分别，p=0.0052；p<0.0001；p=0.0003），而早期AMD组没有显着变化（p=0.86）。还发现了早期AMD与晚期AMD和盘状瘢痕AMD亚组之间的显着差异（分别为p=0.0009和0.0095）。比较健康眼睛和AMD眼睛的中央凹CVD时，发现每个AMD亚组存在显着差异(早期AMD，p=0.011;GA,p<0.0001；晚期AMD，p<0.0001；盘状瘢痕AMD，p<0.0001)。此外，在GA子群中，CVD与EZ中断的延长(p=0.012)和计算的脉络膜视网膜萎缩面积(p=0.009)均呈负相关.
■OCTA可能在AMD的分类中起关键作用，允许评估疾病不同阶段的逐渐流量损害。此外，黄斑和中央凹CVD降低的检测可能有助于揭示AMD的发病机制.
