PDF(Pubmed)
Abstract：
The maintenance of intraocular pressure (IOP) is critical to preserving the pristine optics required for vision. Disturbances in IOP can directly impact the optic nerve and retina, and inner retinal injury can occur following acute and chronic IOP elevation. There are a variety of animal models that have been developed to study the effects of acute and chronic elevation of IOP on the retina, retinal ganglion cell (RGC) morphology, intracellular signaling, gene expression changes, and survival. Acute IOP models induce injury that allows for the study of RGC response to well characterized injury and potential recovery. This review will focus on the initial impact of acute IOP elevation on RGC injury and recovery as these early responses may be the best targets for potential therapeutic interventions to promote RGC survival in glaucoma.
摘要：
眼内压（IOP）的维持对于保持视觉所需的原始光学至关重要。眼压紊乱可直接影响视神经和视网膜,急性和慢性IOP升高后可发生内部视网膜损伤。已经开发了多种动物模型来研究急性和慢性IOP升高对视网膜的影响，视网膜神经节细胞（RGC）形态学，细胞内信号，基因表达变化，和生存。急性IOP模型诱导损伤,其允许研究RGC对充分表征的损伤的应答和潜在恢复。本文将重点关注急性IOP升高对RGC损伤和恢复的初步影响，因为这些早期反应可能是潜在治疗干预措施的最佳目标，以促进青光眼RGC的生存。
