UNASSIGNED: This study was an open-label, cohort study. The study enrolled all patients who were clinical diagnosed as BPH with LUTS and prepared to receive operation of the prostate at the Department of Urology of the Second Hospital of Hebei Medical University. International Prostate Symptom Score (IPSS) were used to evaluate the LUTS of the BPH. And the enrolled patients were divided into four groups, including none, mild HI, moderate HI, and severe HI, based on postoperative pathological results. Then the relationships between HI and IPSS, the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), as well as PSEP were analyzed. Simple and multiple linear regression analyses were performed on the preoperative IPSS and the difference of IPSS before and after surgery was examined. SPSS software version 26 was used for statistical analysis and Prism 9.0 was used to make violin plots.
UNASSIGNED: A total of 69 patients were enrolled in the study. The violin plot results indicated IPSS and NIH-CPSI scores exhibited significant increases in correlation with the severity levels of HI (P<0.001; P<0.001). Among BPH patients with total prostate-specific antigen (t-PSA) levels higher than 4.0 ng/mL, a significant correlation was observed between PSEP levels and HI (P=0.04). Besides, simple and multiple linear regression analysis showed that HI (P<0.001) or PSEP (P=0.03) was significantly associated with IPSS and improvement of LUTS, assessed by postoperative and preoperative IPSS differences.
UNASSIGNED: The study indicated that IPSS and PSEP (when t-PSA >4 ng/mL) were correlated with the severity of HI in patients with BPH. PSEP was linearly correlated with IPSS and the degree of reduction in IPSS after surgery. Consequently, PSEP may serve as a promising predictor for assessing surgical efficacy and diagnosing the severity of HI in patients with BPH.
■这项研究是一个开放的标签,队列研究。该研究招募了在河北医科大学第二医院泌尿外科临床诊断为BPH合并LUTS并准备接受前列腺手术的所有患者。使用国际前列腺症状评分(IPSS)评估BPH的LUTS。将入选的患者分为四组,包括没有,轻度HI,中等HI,严重的HI,根据术后病理结果。然后HI和IPSS之间的关系,美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI),以及PSEP进行了分析。对术前IPSS进行简单和多元线性回归分析,并检查手术前后IPSS的差异。使用SPSS软件26版进行统计分析,并使用Prism9.0制作小提琴图。
■共有69名患者被纳入研究。小提琴作图结果表明IPSS和NIH-CPSI评分与HI严重程度相关显着增加(P<0.001;P<0.001)。在总前列腺特异性抗原(t-PSA)水平高于4.0ng/mL的BPH患者中,PSEP水平与HI之间存在显著相关性(P=0.04).此外,简单和多元线性回归分析显示HI(P<0.001)或PSEP(P=0.03)与IPSS和LUTS改善显著相关,通过术后和术前IPSS差异进行评估。
■研究表明,IPSS和PSEP(当t-PSA>4ng/mL时)与BPH患者的HI严重程度相关。PSEP与IPSS及术后IPSS降低程度呈线性关系。因此,PSEP可能是评估BPH患者手术疗效和诊断HI严重程度的有希望的预测指标。