PDF(Pubmed)
Abstract：
UNASSIGNED: There are no guidelines regarding enteral feeding (EF) of infants with hypoxic-ischemic encephalopathy (HIE) during and shortly after therapeutic hypothermia; consequently, clinical practice is, to date, still variable. The objective of this study is to assess whether a minimal EF strategy during therapeutic hypothermia may be associated with a shorter time to full EF of infants with HIE and to identify the clinical variables that independently affect the time to full EF.
UNASSIGNED: A retrospective study, covering the period from 1 January 2015 to 30 June 2022 was performed at the Neonatal Intensive Care Unit of the Fondazione Policlinico Universitario \"Agostino Gemelli\" IRCCS, Rome, which compared infants with HIE who received minimal EF during therapeutic hypothermia with those who did not.
UNASSIGNED: Seventy-eight infants received minimal EF during therapeutic hypothermia, while 75 did not. Infants who were fed reached full EF significantly faster than those who were not. Moreover, they received parenteral nutrition and maintained central venous lines for a shorter time. A multivariate analysis, taking into account the variable of clinical severity, confirmed that minimal EF is an independent beneficial factor for reaching full EF in a shorter time and mechanical ventilation and seizures are independent factors for a longer time to full EF.
UNASSIGNED: Minimal EF during therapeutic hypothermia is associated with a shorter time to full EF in stable infants with HIE. Further prospective studies are needed to better define the enteral nutrition strategy for infants during therapeutic hypothermia, regardless of the severity of clinical conditions.
UNASSIGNED: A retrospective study, covering the period from 1 January 2015 to 30 June 2022 was performed at the Neonatal Intensive Care Unit of the Fondazione Policlinico Universitario \"Agostino Gemelli\" IRCCS, Rome, which compared infants with HIE who received minimal EF during therapeutic hypothermia with those who did not.
UNASSIGNED: Seventy-eight infants received minimal EF during therapeutic hypothermia, while 75 did not. Infants who were fed reached full EF significantly faster than those who were not. Moreover, they received parenteral nutrition and maintained central venous lines for a shorter time. A multivariate analysis, taking into account the variable of clinical severity, confirmed that minimal EF is an independent beneficial factor for reaching full EF in a shorter time and mechanical ventilation and seizures are independent factors for a longer time to full EF.
UNASSIGNED: Minimal EF during therapeutic hypothermia is associated with a shorter time to full EF in stable infants with HIE. Further prospective studies are needed to better define the enteral nutrition strategy for infants during therapeutic hypothermia, regardless of the severity of clinical conditions.
摘要：
■没有关于治疗性低温期间和之后不久的缺氧缺血性脑病（HIE）婴儿的肠内喂养（EF）的指南；因此，临床实践是，到目前为止,仍然可变。这项研究的目的是评估治疗性低温期间的最小EF策略是否可能与HIE婴儿达到完全EF的较短时间相关，并确定独立影响达到完全EF的时间的临床变量。
■一项回顾性研究，涵盖2015年1月1日至2022年6月30日期间在FondazionePoliclinico大学“AgostinoGemelli”IRCCS的新生儿重症监护病房进行，罗马,比较了在治疗性低温期间接受最低EF的HIE婴儿与未接受EF的HIE婴儿。
■78名婴儿在治疗性低温期间接受了最低EF，75没有。喂食的婴儿比未喂食的婴儿达到全EF的速度快得多。此外，他们接受肠外营养并维持中心静脉导管的时间较短.多变量分析，考虑到临床严重程度的变量，确认最小EF是在较短时间内达到完全EF的独立有益因素，机械通气和癫痫发作是较长时间达到完全EF的独立因素。
■治疗性低温期间的最小EF与HIE稳定婴儿达到完全EF的时间较短有关。需要进一步的前瞻性研究来更好地定义治疗性低温期间婴儿的肠内营养策略。无论临床疾病的严重程度。
■一项回顾性研究，涵盖2015年1月1日至2022年6月30日期间在FondazionePoliclinico大学“AgostinoGemelli”IRCCS的新生儿重症监护病房进行，罗马,比较了在治疗性低温期间接受最低EF的HIE婴儿与未接受EF的HIE婴儿。
■78名婴儿在治疗性低温期间接受了最低EF，75没有。喂食的婴儿比未喂食的婴儿达到全EF的速度快得多。此外，他们接受肠外营养并维持中心静脉导管的时间较短.多变量分析，考虑到临床严重程度的变量，确认最小EF是在较短时间内达到完全EF的独立有益因素，机械通气和癫痫发作是较长时间达到完全EF的独立因素。
■治疗性低温期间的最小EF与HIE稳定婴儿达到完全EF的时间较短有关。需要进一步的前瞻性研究来更好地定义治疗性低温期间婴儿的肠内营养策略。无论临床疾病的严重程度。
