PDF(Pubmed)
Abstract：
UNASSIGNED: While prevalence estimates differ by definition of metabolic syndrome (MetS), it is less clear how different definitions affect associations with alcohol consumption.
UNASSIGNED: We included 3051 adults aged 25-77 from the baseline examination of the Swedish INTERGENE cohort (2001-2004). Using multiple logistic regression, we investigated cross-sectional associations between ethanol intake and MetS defined according to the Adult Treatment Panel III (ATP III), the International Diabetes Federation (IDF), and the Joint Interim Statement (JIS). Alcohol exposure categories comprised abstinence, and low, medium, and high consumption defined via sex-specific tertiles of ethanol intake among current consumers. Covariates included sociodemographics, health, and lifestyle factors.
UNASSIGNED: MetS prevalence estimates varied between 13.9 % (ATP III) and 25.3 % (JIS), with higher prevalence in men than women. Adjusted for age and sex, medium-high alcohol consumption was associated with lower odds of MetS compared to low consumption, while no difference was observed for abstainers. Only the most specific (and thus severe) definition of MetS (ATP III) showed decreasing odds for ethanol intake when adjusted for all covariates.
UNASSIGNED: Our study shows that alcohol-related associations differ by definition of MetS. The finding that individuals with the most stringently defined MetS may benefit from alcohol consumption calls for further well-controlled studies.
UNASSIGNED: We included 3051 adults aged 25-77 from the baseline examination of the Swedish INTERGENE cohort (2001-2004). Using multiple logistic regression, we investigated cross-sectional associations between ethanol intake and MetS defined according to the Adult Treatment Panel III (ATP III), the International Diabetes Federation (IDF), and the Joint Interim Statement (JIS). Alcohol exposure categories comprised abstinence, and low, medium, and high consumption defined via sex-specific tertiles of ethanol intake among current consumers. Covariates included sociodemographics, health, and lifestyle factors.
UNASSIGNED: MetS prevalence estimates varied between 13.9 % (ATP III) and 25.3 % (JIS), with higher prevalence in men than women. Adjusted for age and sex, medium-high alcohol consumption was associated with lower odds of MetS compared to low consumption, while no difference was observed for abstainers. Only the most specific (and thus severe) definition of MetS (ATP III) showed decreasing odds for ethanol intake when adjusted for all covariates.
UNASSIGNED: Our study shows that alcohol-related associations differ by definition of MetS. The finding that individuals with the most stringently defined MetS may benefit from alcohol consumption calls for further well-controlled studies.
摘要：
■虽然患病率估计因代谢综合征(MetS)的定义而异，尚不清楚不同的定义如何影响与饮酒的关联。
■我们从瑞典INTERGENE队列（2001-2004）的基线检查中纳入了3051名25-77岁的成年人。使用多元逻辑回归，我们调查了乙醇摄入量与根据成人治疗小组III（ATPIII）定义的MetS之间的横截面关联，国际糖尿病联合会(IDF)和联合临时声明(JIS)。酒精暴露类别包括禁欲，低,中等,以及通过当前消费者中特定性别的乙醇摄入量定义的高消费量。协变量包括社会人口统计学，健康,和生活方式因素。
■MetS患病率估计值在13.9%（ATPIII）和25.3%（JIS）之间变化，男性患病率高于女性。根据年龄和性别调整，与低饮酒量相比，中高饮酒量与较低的MetS几率相关，而弃权者没有观察到差异。当针对所有协变量进行调整时，只有MetS（ATPIII）的最具体（因此最严重）定义显示乙醇摄入量的几率降低。
■我们的研究表明，与酒精相关的关联因MetS的定义而有所不同。发现具有最严格定义的MetS的个体可能会从饮酒中受益，这一发现要求进一步进行良好的对照研究。
■我们从瑞典INTERGENE队列（2001-2004）的基线检查中纳入了3051名25-77岁的成年人。使用多元逻辑回归，我们调查了乙醇摄入量与根据成人治疗小组III（ATPIII）定义的MetS之间的横截面关联，国际糖尿病联合会(IDF)和联合临时声明(JIS)。酒精暴露类别包括禁欲，低,中等,以及通过当前消费者中特定性别的乙醇摄入量定义的高消费量。协变量包括社会人口统计学，健康,和生活方式因素。
■MetS患病率估计值在13.9%（ATPIII）和25.3%（JIS）之间变化，男性患病率高于女性。根据年龄和性别调整，与低饮酒量相比，中高饮酒量与较低的MetS几率相关，而弃权者没有观察到差异。当针对所有协变量进行调整时，只有MetS（ATPIII）的最具体（因此最严重）定义显示乙醇摄入量的几率降低。
■我们的研究表明，与酒精相关的关联因MetS的定义而有所不同。发现具有最严格定义的MetS的个体可能会从饮酒中受益，这一发现要求进一步进行良好的对照研究。
