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Abstract：
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are novel inflammatory indicators that can be used to predict the severity and prognosis of various diseases. We categorize acute pancreatitis by etiology into acute biliary pancreatitis (ABP) and hypertriglyceridemia-induced acute pancreatitis (HTGP).
OBJECTIVE: To investigate the clinical significance of NLR and PLR in assessing persistent organ failure (POF) in HTGP and ABP.
METHODS: A total of 1450 patients diagnosed with acute pancreatitis (AP) for the first time at Shanxi Bethune Hospital between January 2012 and January 2023 were enrolled. The patients were categorized into two groups according to the etiology of AP: ABP in 530 patients and HTGP in 241 patients. We collected and compared the clinical data of the patients, including NLR, PLR, and AP prognostic scoring systems, within 48 h of hospital admission.
RESULTS: The NLR (9.1 vs 6.9, P < 0.001) and PLR (203.1 vs 160.5, P < 0.001) were significantly higher in the ABP group than in the HTGP group. In the HTGP group, both NLR and PLR were significantly increased in patients with severe AP and those with a SOFA score ≥ 3. Likewise, in the ABP group, NLR and PLR were significantly elevated in patients with severe AP, modified computed tomography severity index score ≥ 4, Japanese Severity Score ≥ 3, and modified Marshall score ≥ 2. Moreover, NLR and PLR showed predictive value for the development of POF in both the ABP and HTGP groups.
CONCLUSIONS: NLR and PLR vary between ABP and HTGP, are strongly associated with AP prognostic scoring systems, and have predictive potential for the occurrence of POF in both ABP and HTGP.
OBJECTIVE: To investigate the clinical significance of NLR and PLR in assessing persistent organ failure (POF) in HTGP and ABP.
METHODS: A total of 1450 patients diagnosed with acute pancreatitis (AP) for the first time at Shanxi Bethune Hospital between January 2012 and January 2023 were enrolled. The patients were categorized into two groups according to the etiology of AP: ABP in 530 patients and HTGP in 241 patients. We collected and compared the clinical data of the patients, including NLR, PLR, and AP prognostic scoring systems, within 48 h of hospital admission.
RESULTS: The NLR (9.1 vs 6.9, P < 0.001) and PLR (203.1 vs 160.5, P < 0.001) were significantly higher in the ABP group than in the HTGP group. In the HTGP group, both NLR and PLR were significantly increased in patients with severe AP and those with a SOFA score ≥ 3. Likewise, in the ABP group, NLR and PLR were significantly elevated in patients with severe AP, modified computed tomography severity index score ≥ 4, Japanese Severity Score ≥ 3, and modified Marshall score ≥ 2. Moreover, NLR and PLR showed predictive value for the development of POF in both the ABP and HTGP groups.
CONCLUSIONS: NLR and PLR vary between ABP and HTGP, are strongly associated with AP prognostic scoring systems, and have predictive potential for the occurrence of POF in both ABP and HTGP.
摘要：
背景：中性粒细胞与淋巴细胞之比（NLR）和血小板与淋巴细胞之比（PLR）是新的炎症指标，可用于预测各种疾病的严重程度和预后。我们根据病因将急性胰腺炎分为急性胆源性胰腺炎（ABP）和高甘油三酯血症引起的急性胰腺炎（HTGP）。
目的：探讨NLR和PLR在评估HTGP和ABP持续性器官衰竭（POF）中的临床意义。
方法：选取2012年1月至2023年1月在山西省白求恩医院首次诊断为急性胰腺炎（AP）的1450例患者。根据AP的病因将患者分为两组：530例患者为ABP，241例患者为HTGP。我们收集并比较了患者的临床资料，包括NLR,PLR,和AP预后评分系统，入院后48小时内。
结果：ABP组的NLR（9.1vs6.9，P<0.001）和PLR（203.1vs160.5，P<0.001）明显高于HTGP组。在HTGP组中，在重度AP患者和SOFA评分≥3的患者中,NLR和PLR均显著升高.同样，在ABP组中，严重AP患者的NLR和PLR显著升高，改良计算机断层扫描严重度指数评分≥4,日本严重度评分≥3,改良马歇尔评分≥2。此外，NLR和PLR对ABP和HTGP组POF的发展均具有预测价值。
结论：NLR和PLR在ABP和HTGP之间有所不同，与AP预后评分系统密切相关，并且在ABP和HTGP中均具有POF发生的预测潜力。
目的：探讨NLR和PLR在评估HTGP和ABP持续性器官衰竭（POF）中的临床意义。
方法：选取2012年1月至2023年1月在山西省白求恩医院首次诊断为急性胰腺炎（AP）的1450例患者。根据AP的病因将患者分为两组：530例患者为ABP，241例患者为HTGP。我们收集并比较了患者的临床资料，包括NLR,PLR,和AP预后评分系统，入院后48小时内。
结果：ABP组的NLR（9.1vs6.9，P<0.001）和PLR（203.1vs160.5，P<0.001）明显高于HTGP组。在HTGP组中，在重度AP患者和SOFA评分≥3的患者中,NLR和PLR均显著升高.同样，在ABP组中，严重AP患者的NLR和PLR显著升高，改良计算机断层扫描严重度指数评分≥4,日本严重度评分≥3,改良马歇尔评分≥2。此外，NLR和PLR对ABP和HTGP组POF的发展均具有预测价值。
结论：NLR和PLR在ABP和HTGP之间有所不同，与AP预后评分系统密切相关，并且在ABP和HTGP中均具有POF发生的预测潜力。
