PDF(Pubmed)
Abstract：
UNASSIGNED: Some occupational and environmental exposures could increase the risk of chronic obstructive pulmonary disease (COPD) and hypertension in various work and living environments. However, the effect of exposure to multiple exogenous harmful substances on COPD and hypertension co-morbidities remains unclear.
UNASSIGNED: Participants were selected from eight hospitals in five provinces in China using a multistage cluster sampling procedure. Participants\' demographic, exposure, and disease information were collected through questionnaires, spirometry, and blood pressure examinations. Demographic data were used as matching factors, and 1:1 matching between the exposed and non-exposed groups was performed by employing propensity score matching (PSM) to minimize the influence on the results. A one-way chi-squared analysis and multifactorial logistic regression were used to analyze the association between the exposure to exogenous harmful substances (metals and their compound dust, inorganic mineral dust, organic chemicals, and livestock by-products) and the co-morbidity of COPD and hypertension.
UNASSIGNED: There were 6,610 eligible participants in the final analysis, of whom 2,045 (30.9%) were exposed to exogenous harmful substances. The prevalence of co-morbidities of COPD and hypertension (6.0%) in the exposure group was higher than their prevalence in the total population (4.6%). After PSM, exogenous harmful substance exposure was found to be a risk factor for the co-morbidity of COPD and hypertension [odds ratio (OR) = 1.347, 95% confidence interval (CI): 1.011-1.794], which was not statistically significant before PSM (OR = 1.094, 95% CI: 0.852-1.405). Meanwhile, the results of different outcomes showed that the association between hypertension and exogenous harmful substance exposure was not statistically significant (OR = 0.965, 95% CI: 0.846-1.101). Smoking (OR = 4.702, 95% CI: 3.321-6.656), history of a respiratory disease during childhood (OR = 2.830, 95% CI: 1.600-5.006), and history of respiratory symptoms (OR = 1.897, 95% CI: 1.331-2.704) were also identified as risk factors for the co-morbidity of COPD and hypertension.
UNASSIGNED: The distribution of exogenous harmful substance exposure varies in the population, and the prevalence of co-morbidities is generally higher in susceptible populations. Exposure to exogenous harmful substances was found to be a key risk factor after adjusting for demographic confounders.
UNASSIGNED: Participants were selected from eight hospitals in five provinces in China using a multistage cluster sampling procedure. Participants\' demographic, exposure, and disease information were collected through questionnaires, spirometry, and blood pressure examinations. Demographic data were used as matching factors, and 1:1 matching between the exposed and non-exposed groups was performed by employing propensity score matching (PSM) to minimize the influence on the results. A one-way chi-squared analysis and multifactorial logistic regression were used to analyze the association between the exposure to exogenous harmful substances (metals and their compound dust, inorganic mineral dust, organic chemicals, and livestock by-products) and the co-morbidity of COPD and hypertension.
UNASSIGNED: There were 6,610 eligible participants in the final analysis, of whom 2,045 (30.9%) were exposed to exogenous harmful substances. The prevalence of co-morbidities of COPD and hypertension (6.0%) in the exposure group was higher than their prevalence in the total population (4.6%). After PSM, exogenous harmful substance exposure was found to be a risk factor for the co-morbidity of COPD and hypertension [odds ratio (OR) = 1.347, 95% confidence interval (CI): 1.011-1.794], which was not statistically significant before PSM (OR = 1.094, 95% CI: 0.852-1.405). Meanwhile, the results of different outcomes showed that the association between hypertension and exogenous harmful substance exposure was not statistically significant (OR = 0.965, 95% CI: 0.846-1.101). Smoking (OR = 4.702, 95% CI: 3.321-6.656), history of a respiratory disease during childhood (OR = 2.830, 95% CI: 1.600-5.006), and history of respiratory symptoms (OR = 1.897, 95% CI: 1.331-2.704) were also identified as risk factors for the co-morbidity of COPD and hypertension.
UNASSIGNED: The distribution of exogenous harmful substance exposure varies in the population, and the prevalence of co-morbidities is generally higher in susceptible populations. Exposure to exogenous harmful substances was found to be a key risk factor after adjusting for demographic confounders.
摘要：
■某些职业和环境暴露会增加各种工作和生活环境中慢性阻塞性肺疾病（COPD）和高血压的风险。然而,暴露于多种外源性有害物质对COPD和高血压合并症的影响尚不清楚.
■使用多阶段整群抽样程序从中国五个省份的八所医院中选择参与者。参与者\'人口统计，暴露,通过问卷收集疾病信息，肺活量测定,和血压检查。人口统计数据被用作匹配因素，暴露组和非暴露组之间的1:1匹配通过使用倾向评分匹配(PSM)来最小化对结果的影响。采用单因素卡方分析和多因素logistic回归分析了暴露于外源性有害物质（金属及其复合粉尘，无机矿物粉尘，有机化学品,和牲畜副产品）以及COPD和高血压的合并症。
■最终分析中有6,610名合格参与者，其中2045人(30.9%)暴露于外源性有害物质。暴露组中COPD和高血压合并症的患病率（6.0％）高于其在总人口中的患病率（4.6％）。PSM之后,发现外源性有害物质暴露是COPD和高血压合并症的危险因素[比值比（OR）=1.347，95％置信区间（CI）：1.011-1.794]，PSM前无统计学意义(OR=1.094,95%CI:0.852-1.405)。同时,不同结局的结果显示,高血压与外源性有害物质暴露的相关性无统计学意义(OR=0.965,95%CI:0.846~1.101).吸烟（OR=4.702，95%CI：3.321-6.656），儿童期呼吸系统疾病史（OR=2.830，95%CI：1.600-5.006），呼吸道症状史(OR=1.897,95%CI:1.331~2.704)也被确定为COPD和高血压合并症的危险因素.
■外源性有害物质暴露在人群中的分布各不相同，易感人群中合并症的患病率普遍较高。在调整了人口混杂因素后，发现暴露于外源性有害物质是一个关键的危险因素。
■使用多阶段整群抽样程序从中国五个省份的八所医院中选择参与者。参与者\'人口统计，暴露,通过问卷收集疾病信息，肺活量测定,和血压检查。人口统计数据被用作匹配因素，暴露组和非暴露组之间的1:1匹配通过使用倾向评分匹配(PSM)来最小化对结果的影响。采用单因素卡方分析和多因素logistic回归分析了暴露于外源性有害物质（金属及其复合粉尘，无机矿物粉尘，有机化学品,和牲畜副产品）以及COPD和高血压的合并症。
■最终分析中有6,610名合格参与者，其中2045人(30.9%)暴露于外源性有害物质。暴露组中COPD和高血压合并症的患病率（6.0％）高于其在总人口中的患病率（4.6％）。PSM之后,发现外源性有害物质暴露是COPD和高血压合并症的危险因素[比值比（OR）=1.347，95％置信区间（CI）：1.011-1.794]，PSM前无统计学意义(OR=1.094,95%CI:0.852-1.405)。同时,不同结局的结果显示,高血压与外源性有害物质暴露的相关性无统计学意义(OR=0.965,95%CI:0.846~1.101).吸烟（OR=4.702，95%CI：3.321-6.656），儿童期呼吸系统疾病史（OR=2.830，95%CI：1.600-5.006），呼吸道症状史(OR=1.897,95%CI:1.331~2.704)也被确定为COPD和高血压合并症的危险因素.
■外源性有害物质暴露在人群中的分布各不相同，易感人群中合并症的患病率普遍较高。在调整了人口混杂因素后，发现暴露于外源性有害物质是一个关键的危险因素。
