PDF(Pubmed)
Abstract：
UNASSIGNED: Associations between metabolic risk factors and lung cancer remain elusive, and evidence on the linkage between non-alcoholic fatty liver disease (NAFLD) and pulmonary nodules is limited. This study sought to examine the independent association between NAFLD and the risk of pulmonary nodules.
UNASSIGNED: Cross-sectional analyses of 1,119 patients with intestinal polyps hospitalized at the Department of Gastroenterology, Minhang District Central Hospital of Shanghai, China, were conducted. NAFLD was diagnosed based on hepatic ultrasonography or computed tomography (CT) findings of hepatic steatosis, with exclusion criteria ensuring patients had no history of significant alcohol consumption, viral infections, or hepatic autoimmune diseases. The currently accepted definition of a pulmonary nodule is a solid or sub-solid shadow ≤3 cm in diameter that appears as a solid or semi-solid pattern on a chest CT scan (our specific treatment is pulmonary nodule size: 5 mm to 3 cm). Adjusted 95% confidence intervals (CIs) and odds ratios (ORs) for NAFLD and the clinical features connected with pulmonary nodule risk were determined using a multivariable logistic regression analysis.
UNASSIGNED: Among the 979 intestinal polyp patients, the prevalence rates of NAFLD and pulmonary nodules were 25.9% and 32.8%, respectively. Patients with pulmonary nodules exhibited higher rates of NAFLD (31.5% vs. 23.3%, P=0.006) and obesity (41.4% vs. 32.5%, P=0.006) compared to those without pulmonary nodules. After removing all the possible confounding variables, the adjusted ORs for NAFLD, an older age, smoking, and obesity were 1.370 (95% CI: 1.006-1.867, P=0.04), 1.022 (95% CI: 1.010-1.033), 1.599 (95% CI: 1.033-2.475), and 1.410 (95% CI: 1.057-1.880), respectively (all P values <0.05). NAFLD showed a significant association with an increased risk of pulmonary nodules.
UNASSIGNED: NAFLD was independently linked to an increased incidence of pulmonary nodules in intestinal polyp patients, which emphasizes the importance of screening and managing these conditions in lung cancer prevention.
UNASSIGNED: Cross-sectional analyses of 1,119 patients with intestinal polyps hospitalized at the Department of Gastroenterology, Minhang District Central Hospital of Shanghai, China, were conducted. NAFLD was diagnosed based on hepatic ultrasonography or computed tomography (CT) findings of hepatic steatosis, with exclusion criteria ensuring patients had no history of significant alcohol consumption, viral infections, or hepatic autoimmune diseases. The currently accepted definition of a pulmonary nodule is a solid or sub-solid shadow ≤3 cm in diameter that appears as a solid or semi-solid pattern on a chest CT scan (our specific treatment is pulmonary nodule size: 5 mm to 3 cm). Adjusted 95% confidence intervals (CIs) and odds ratios (ORs) for NAFLD and the clinical features connected with pulmonary nodule risk were determined using a multivariable logistic regression analysis.
UNASSIGNED: Among the 979 intestinal polyp patients, the prevalence rates of NAFLD and pulmonary nodules were 25.9% and 32.8%, respectively. Patients with pulmonary nodules exhibited higher rates of NAFLD (31.5% vs. 23.3%, P=0.006) and obesity (41.4% vs. 32.5%, P=0.006) compared to those without pulmonary nodules. After removing all the possible confounding variables, the adjusted ORs for NAFLD, an older age, smoking, and obesity were 1.370 (95% CI: 1.006-1.867, P=0.04), 1.022 (95% CI: 1.010-1.033), 1.599 (95% CI: 1.033-2.475), and 1.410 (95% CI: 1.057-1.880), respectively (all P values <0.05). NAFLD showed a significant association with an increased risk of pulmonary nodules.
UNASSIGNED: NAFLD was independently linked to an increased incidence of pulmonary nodules in intestinal polyp patients, which emphasizes the importance of screening and managing these conditions in lung cancer prevention.
摘要：
■代谢危险因素与肺癌之间的关联仍然难以捉摸，非酒精性脂肪性肝病（NAFLD）与肺结节之间联系的证据有限。这项研究试图检查NAFLD与肺结节风险之间的独立关联。
■对胃肠病科住院的1,119例肠息肉患者的横断面分析，上海市闵行区中心医院,中国,进行了。根据肝脏超声检查或肝脏脂肪变性计算机断层扫描（CT）发现诊断NAFLD，排除标准确保患者没有显著饮酒史，病毒感染,或肝脏自身免疫性疾病。目前公认的肺结节的定义是直径≤3厘米的实心或亚实心阴影，在胸部CT扫描上表现为实心或半实心图案（我们的具体治疗是肺结节大小：5毫米至3厘米）。使用多变量逻辑回归分析确定NAFLD的调整后95％置信区间（CI）和比值比（OR）以及与肺结节风险相关的临床特征。
■在979例肠息肉患者中，NAFLD和肺结节的患病率分别为25.9%和32.8%,分别。肺结节患者的NAFLD发生率较高(31.5%vs.23.3%,P=0.006）和肥胖（41.4%vs.32.5%,与没有肺结节的人相比，P=0.006）。删除所有可能的混杂变量后，NAFLD的调整后OR，年纪大了,吸烟,肥胖为1.370（95%CI：1.006-1.867，P=0.04），1.022（95%CI：1.010-1.033），1.599（95%CI：1.033-2.475），和1.410（95%CI：1.057-1.880），分别(所有P值<0.05)。NAFLD显示与肺结节风险增加显著相关。
■NAFLD与肠息肉患者肺结节发病率增加独立相关，强调了筛查和管理这些疾病在肺癌预防中的重要性。
■对胃肠病科住院的1,119例肠息肉患者的横断面分析，上海市闵行区中心医院,中国,进行了。根据肝脏超声检查或肝脏脂肪变性计算机断层扫描（CT）发现诊断NAFLD，排除标准确保患者没有显著饮酒史，病毒感染,或肝脏自身免疫性疾病。目前公认的肺结节的定义是直径≤3厘米的实心或亚实心阴影，在胸部CT扫描上表现为实心或半实心图案（我们的具体治疗是肺结节大小：5毫米至3厘米）。使用多变量逻辑回归分析确定NAFLD的调整后95％置信区间（CI）和比值比（OR）以及与肺结节风险相关的临床特征。
■在979例肠息肉患者中，NAFLD和肺结节的患病率分别为25.9%和32.8%,分别。肺结节患者的NAFLD发生率较高(31.5%vs.23.3%,P=0.006）和肥胖（41.4%vs.32.5%,与没有肺结节的人相比，P=0.006）。删除所有可能的混杂变量后，NAFLD的调整后OR，年纪大了,吸烟,肥胖为1.370（95%CI：1.006-1.867，P=0.04），1.022（95%CI：1.010-1.033），1.599（95%CI：1.033-2.475），和1.410（95%CI：1.057-1.880），分别(所有P值<0.05)。NAFLD显示与肺结节风险增加显著相关。
■NAFLD与肠息肉患者肺结节发病率增加独立相关，强调了筛查和管理这些疾病在肺癌预防中的重要性。
