PDF(Pubmed)
Abstract：
Chloroquine is a common antimalarial drug and is listed in the World Health Organization Standard List of Essential Medicines because of its safety, low cost and ease of use. Besides its antimalarial property, chloroquine also was used in anti-inflammatory and antivirus, especially in antitumor therapy. A mount of data showed that chloroquine mainly relied on autophagy inhibition to exert its antitumor effects. However, recently, more and more researches have revealed that chloroquine acts through other mechanisms that are autophagy-independent. Nevertheless, the current reviews lacked a comprehensive summary of the antitumor mechanism and combined pharmacotherapy of chloroquine. So here we focused on the antitumor properties of chloroquine, summarized the pharmacological mechanisms of antitumor progression of chloroquine dependent or independent of autophagy inhibition. Moreover, we also discussed the side effects and possible application developments of chloroquine. This review provided a more systematic and cutting-edge knowledge involved in the anti-tumor mechanisms and combined pharmacotherapy of chloroquine in hope of carrying out more in-depth exploration of chloroquine and obtaining more clinical applications.
摘要：
氯喹是一种常见的抗疟药,因其安全性被列入世界卫生组织基本药物标准目录,低成本和易用性。除了它的抗疟药，氯喹还用于抗炎和抗病毒，尤其是在抗肿瘤治疗中。大量数据表明，氯喹主要依靠自噬抑制来发挥其抗肿瘤作用。然而,最近,越来越多的研究表明，氯喹通过其他不依赖自噬的机制发挥作用。然而，目前的综述缺乏对氯喹的抗肿瘤机制和联合药物治疗的全面总结。所以在这里我们专注于氯喹的抗肿瘤特性，总结了氯喹依赖或不依赖自噬抑制的抗肿瘤进展的药理机制。此外，我们还讨论了氯喹的副作用和可能的应用进展。本综述对氯喹的抗肿瘤机制及联合药物治疗提供了较为系统和前沿的知识,以期对氯喹进行更深入的探索,获得更多的临床应用。
