PDF(Pubmed)
Abstract：
UNASSIGNED: Tolerance Induction Program (TIP) immunotherapy applies machine learning contextualized on immunologic and food protein data sets. TIP has established efficacy toward peanut allergy. This form of treatment demonstrates equal efficacy toward cow\'s milk anaphylaxis. TIP maintains remission outcomes defined as a minimum of 7 days of allergen unresponsiveness to high-dose protein exposures. Furthermore, remission patients openly consume unrestricted amounts of dairy protein.
UNASSIGNED: We sought to assess the rate of decline in specific IgE specific whole and component-resolved diagnostics following 1 year of TIP milk immunotherapy.
UNASSIGNED: The study comprised 214 cow milk anaphylactic children who underwent TIP at the Translational Pulmonary & Immunology Research Center/Food Allergy Institute. Postintervention changes in cow milk specific IgE, component-resolved diagnostics, and specific IgG4 were assessed.
UNASSIGNED: After 1 year of 10-g dairy protein weekly sustained unresponsiveness, eosinophil count decreased from 558.38 to 409.26 cells/μL, the mean cow milk IgE decreased from 16.91 to 9.10 kU/L, the mean boiled cow milk IgE decreased from 12.89 to 6.03 kU/L, the mean Bos D4 decreased from 7.38 to 3.52 kU/L, the mean Bos D5 decreased from 6.79 to 3.16 kU/L, and the mean Bos D8 decreased from 13.55 to 6.62 kU/L. Adverse events were rare.
UNASSIGNED: TIP cow milk immunotherapy significantly reduced cow milk specific IgE and component-resolved diagnostics while increasing specific IgG4 in cow milk anaphylactic children. TIP demonstrates safety and clinical efficacy in cow milk anaphylaxis treatment.
UNASSIGNED: We sought to assess the rate of decline in specific IgE specific whole and component-resolved diagnostics following 1 year of TIP milk immunotherapy.
UNASSIGNED: The study comprised 214 cow milk anaphylactic children who underwent TIP at the Translational Pulmonary & Immunology Research Center/Food Allergy Institute. Postintervention changes in cow milk specific IgE, component-resolved diagnostics, and specific IgG4 were assessed.
UNASSIGNED: After 1 year of 10-g dairy protein weekly sustained unresponsiveness, eosinophil count decreased from 558.38 to 409.26 cells/μL, the mean cow milk IgE decreased from 16.91 to 9.10 kU/L, the mean boiled cow milk IgE decreased from 12.89 to 6.03 kU/L, the mean Bos D4 decreased from 7.38 to 3.52 kU/L, the mean Bos D5 decreased from 6.79 to 3.16 kU/L, and the mean Bos D8 decreased from 13.55 to 6.62 kU/L. Adverse events were rare.
UNASSIGNED: TIP cow milk immunotherapy significantly reduced cow milk specific IgE and component-resolved diagnostics while increasing specific IgG4 in cow milk anaphylactic children. TIP demonstrates safety and clinical efficacy in cow milk anaphylaxis treatment.
摘要：
■耐受性诱导计划（TIP）免疫疗法将机器学习应用于免疫和食物蛋白质数据集。TIP已确定对花生过敏的功效。这种形式的治疗对牛乳过敏反应具有同等效力。TIP维持缓解结果，定义为至少7天过敏原对高剂量蛋白质暴露无反应。此外，缓解期患者公开食用不受限制的乳制品蛋白质。
■我们试图评估TIP牛奶免疫治疗1年后特异性IgE特异性整体和成分分辨诊断的下降率。
■该研究包括214名牛奶过敏儿童，他们在转化肺和免疫学研究中心/食物过敏研究所接受了TIP。干预后牛奶特异性IgE的变化，组件解析诊断,和特异性IgG4进行评估。
■每周服用10克乳制品蛋白1年后持续无反应，嗜酸性粒细胞计数从558.38降至409.26细胞/μL，平均牛奶IgE从16.91下降到9.10kU/L，平均煮牛奶IgE从12.89下降到6.03kU/L，平均BosD4从7.38下降到3.52kU/L，平均BosD5从6.79下降到3.16kU/L，平均BosD8从13.55下降到6.62kU/L。不良事件很少见。
■TIP牛奶免疫疗法显着降低了牛奶特异性IgE和成分分辨诊断，同时增加了牛奶过敏儿童的特异性IgG4。TIP证明了牛奶过敏反应治疗的安全性和临床疗效。
■我们试图评估TIP牛奶免疫治疗1年后特异性IgE特异性整体和成分分辨诊断的下降率。
■该研究包括214名牛奶过敏儿童，他们在转化肺和免疫学研究中心/食物过敏研究所接受了TIP。干预后牛奶特异性IgE的变化，组件解析诊断,和特异性IgG4进行评估。
■每周服用10克乳制品蛋白1年后持续无反应，嗜酸性粒细胞计数从558.38降至409.26细胞/μL，平均牛奶IgE从16.91下降到9.10kU/L，平均煮牛奶IgE从12.89下降到6.03kU/L，平均BosD4从7.38下降到3.52kU/L，平均BosD5从6.79下降到3.16kU/L，平均BosD8从13.55下降到6.62kU/L。不良事件很少见。
■TIP牛奶免疫疗法显着降低了牛奶特异性IgE和成分分辨诊断，同时增加了牛奶过敏儿童的特异性IgG4。TIP证明了牛奶过敏反应治疗的安全性和临床疗效。
