UNASSIGNED: We sought to assess the rate of decline in specific IgE specific whole and component-resolved diagnostics following 1 year of TIP milk immunotherapy.
UNASSIGNED: The study comprised 214 cow milk anaphylactic children who underwent TIP at the Translational Pulmonary & Immunology Research Center/Food Allergy Institute. Postintervention changes in cow milk specific IgE, component-resolved diagnostics, and specific IgG4 were assessed.
UNASSIGNED: After 1 year of 10-g dairy protein weekly sustained unresponsiveness, eosinophil count decreased from 558.38 to 409.26 cells/μL, the mean cow milk IgE decreased from 16.91 to 9.10 kU/L, the mean boiled cow milk IgE decreased from 12.89 to 6.03 kU/L, the mean Bos D4 decreased from 7.38 to 3.52 kU/L, the mean Bos D5 decreased from 6.79 to 3.16 kU/L, and the mean Bos D8 decreased from 13.55 to 6.62 kU/L. Adverse events were rare.
UNASSIGNED: TIP cow milk immunotherapy significantly reduced cow milk specific IgE and component-resolved diagnostics while increasing specific IgG4 in cow milk anaphylactic children. TIP demonstrates safety and clinical efficacy in cow milk anaphylaxis treatment.
■我们试图评估TIP牛奶免疫治疗1年后特异性IgE特异性整体和成分分辨诊断的下降率。
■该研究包括214名牛奶过敏儿童,他们在转化肺和免疫学研究中心/食物过敏研究所接受了TIP。干预后牛奶特异性IgE的变化,组件解析诊断,和特异性IgG4进行评估。
■每周服用10克乳制品蛋白1年后持续无反应,嗜酸性粒细胞计数从558.38降至409.26细胞/μL,平均牛奶IgE从16.91下降到9.10kU/L,平均煮牛奶IgE从12.89下降到6.03kU/L,平均BosD4从7.38下降到3.52kU/L,平均BosD5从6.79下降到3.16kU/L,平均BosD8从13.55下降到6.62kU/L。不良事件很少见。
■TIP牛奶免疫疗法显着降低了牛奶特异性IgE和成分分辨诊断,同时增加了牛奶过敏儿童的特异性IgG4。TIP证明了牛奶过敏反应治疗的安全性和临床疗效。