PDF(Pubmed)
Abstract：
UNASSIGNED: To assess and compare choroidal morphometric vascular parameters, using optical coherence tomographic angiography (OCTA), in highly myopic adults with and without myopic macular degeneration (MMD).
UNASSIGNED: This is a clinic-based observational study of 148 eyes with axial length (AL) ≥25mm, enrolled from the high myopia clinic of the Singapore National Eye Centre. MMD was graded from fundus photographs. Swept source OCT (SS-OCT) and OCTA were performed and assessed for choroidal layer thickness (CT) and choroidal vasculature (choroidal vessel density (CVD), choroidal branch area (CBA) and mean choroidal vessel width (MCVW)) in the different choroidal layers (overall choroidal layer (CL), medium-vessel choroidal layer (MVCL), large-vessel choroidal layer (LVCL)).
UNASSIGNED: CTCL (r=-0.58, p<0.001), CTMVCL (r=-0.22, p=0.04), MCVWCL (r=-0.58, p<0.001), and CVDCL (r=-0.19, p=0.02) were negatively correlated with AL, while CBACL (r=0.61, p<0.001) was positively correlated. Compared to eyes with no MMD, eyes with MMD2 had lower CTCL (120.37±47.18µm vs 218.33±92.70µm, p<0.001), CTMVCL (70.57±15.28µm vs 85.32±23.71µm, p=0.04), CTLVCL (101.65±25.36µm vs 154.55±68.41µm, p=0.001) and greater CVDCL (71.10±3.97% vs 66.97±3.63%, p<0.001), CVDMVCL (66.96±2.35% vs 65.06±2.69%, p=0.002), CVDLVCL (68.36±2.56% vs 66.58±2.88%, p=0.012), MCVWMVCL (6.14±0.34µm vs 5.90±0.35µm, p=0.007), and CBACL (12.69±1.38% vs 11.34±1.18%, p<0.001). After adjusting for age, thicker CTCL (odds ratio (OR) 0.98, 95% confidence interval (CI) 0.97-0.99, p<0.001), CTMVCL (OR 0.97 (0.94-0.99), p=0.002) and CTLVCL (OR 0.97 (0.96-0.98, p<0.001) were significantly associated with lower odds of MMD2, while increased CVDCL (OR 1.37 (1.20-1.55), p<0.001), CVDMVCL (OR 1.39 (1.12-1.73), p=0.003), CVDLVCL (OR 1.31 (1.07-1.60), p=0.009), CBACL (OR 2.19 (1.55-3.08), p<0.001) and MCVWMVCL (OR 6.97 (1.59-30.51), p=0.01) was significantly associated with higher odds of MMD2.
UNASSIGNED: Decrease in choroidal vessel width, density and thickness, and an increase in vascular branching were observed in eyes with long AL. A thinner and denser choroid with greater branching area and vessel width, which may all be signs of hypoxia, were associated with greater odds of MMD2.
UNASSIGNED: This is a clinic-based observational study of 148 eyes with axial length (AL) ≥25mm, enrolled from the high myopia clinic of the Singapore National Eye Centre. MMD was graded from fundus photographs. Swept source OCT (SS-OCT) and OCTA were performed and assessed for choroidal layer thickness (CT) and choroidal vasculature (choroidal vessel density (CVD), choroidal branch area (CBA) and mean choroidal vessel width (MCVW)) in the different choroidal layers (overall choroidal layer (CL), medium-vessel choroidal layer (MVCL), large-vessel choroidal layer (LVCL)).
UNASSIGNED: CTCL (r=-0.58, p<0.001), CTMVCL (r=-0.22, p=0.04), MCVWCL (r=-0.58, p<0.001), and CVDCL (r=-0.19, p=0.02) were negatively correlated with AL, while CBACL (r=0.61, p<0.001) was positively correlated. Compared to eyes with no MMD, eyes with MMD2 had lower CTCL (120.37±47.18µm vs 218.33±92.70µm, p<0.001), CTMVCL (70.57±15.28µm vs 85.32±23.71µm, p=0.04), CTLVCL (101.65±25.36µm vs 154.55±68.41µm, p=0.001) and greater CVDCL (71.10±3.97% vs 66.97±3.63%, p<0.001), CVDMVCL (66.96±2.35% vs 65.06±2.69%, p=0.002), CVDLVCL (68.36±2.56% vs 66.58±2.88%, p=0.012), MCVWMVCL (6.14±0.34µm vs 5.90±0.35µm, p=0.007), and CBACL (12.69±1.38% vs 11.34±1.18%, p<0.001). After adjusting for age, thicker CTCL (odds ratio (OR) 0.98, 95% confidence interval (CI) 0.97-0.99, p<0.001), CTMVCL (OR 0.97 (0.94-0.99), p=0.002) and CTLVCL (OR 0.97 (0.96-0.98, p<0.001) were significantly associated with lower odds of MMD2, while increased CVDCL (OR 1.37 (1.20-1.55), p<0.001), CVDMVCL (OR 1.39 (1.12-1.73), p=0.003), CVDLVCL (OR 1.31 (1.07-1.60), p=0.009), CBACL (OR 2.19 (1.55-3.08), p<0.001) and MCVWMVCL (OR 6.97 (1.59-30.51), p=0.01) was significantly associated with higher odds of MMD2.
UNASSIGNED: Decrease in choroidal vessel width, density and thickness, and an increase in vascular branching were observed in eyes with long AL. A thinner and denser choroid with greater branching area and vessel width, which may all be signs of hypoxia, were associated with greater odds of MMD2.
摘要：
■为了评估和比较脉络膜血管形态参数，使用光学相干断层血管造影（OCTA），患有和不患有近视性黄斑变性（MMD）的高度近视成年人。
■这是一项基于临床的观察性研究，对148只眼的眼轴长度（AL）≥25mm，从新加坡国家眼科中心的高度近视诊所注册。根据眼底照片对MMD进行分级。扫描源OCT(SS-OCT)和OCTA进行脉络膜层厚度(CT)和脉络膜血管(脉络膜血管密度(CVD),脉络膜分支面积（CBA）和平均脉络膜血管宽度（MCVW））在不同脉络膜层（整体脉络膜层（CL），中血管脉络膜层（MVCL），大血管脉络膜层（LVCL））。
■CTCL（r=-0.58，p<0.001），CTMVCL（r=-0.22，p=0.04），MCVWCL（r=-0.58，p<0.001），CVDCL(r=-0.19,p=0.02)与AL呈负相关,而CBACL呈正相关(r=0.61,p<0.001)。与没有MMD的眼睛相比，患有MMD2的眼睛CTCL较低（120.37±47.18µmvs218.33±92.70µm，p<0.001)，CTMVCL(70.57±15.28µmvs85.32±23.71µm,p=0.04),CTLVCL(101.65±25.36µmvs154.55±68.41µm,p=0.001）和更大的CVDCL（71.10±3.97％vs66.97±3.63％，p<0.001)，CVDMVCL（66.96±2.35%vs65.06±2.69%，p=0.002),CVDLVCL（68.36±2.56%vs66.58±2.88%，p=0.012),MCVWMVCL(6.14±0.34µmvs5.90±0.35µm,p=0.007),和CBACL（12.69±1.38%vs11.34±1.18%，p<0.001)。在调整了年龄之后,厚CTCL(比值比(OR)0.98，95%置信区间(CI)0.97-0.99，p<0.001)，CTMVCL（OR0.97（0.94-0.99），p=0.002）和CTLVCL（OR0.97（0.96-0.98，p<0.001）与MMD2的较低几率显着相关，而CVDCL增加（OR1.37（1.20-1.55），p<0.001)，CVDMVCL（OR1.39（1.12-1.73），p=0.003),CVDLVCL（OR1.31（1.07-1.60），p=0.009),CBACL（或2.19（1.55-3.08），p<0.001)和MCVWMVCL(OR6.97(1.59-30.51)，p=0.01）与MMD2的较高几率显着相关。
■脉络膜血管宽度减小，密度和厚度，在长AL眼中观察到血管分支增加。脉络膜更薄、更密，分支面积和血管宽度更大，这些都可能是缺氧的迹象，与MMD2的更大几率相关。
■这是一项基于临床的观察性研究，对148只眼的眼轴长度（AL）≥25mm，从新加坡国家眼科中心的高度近视诊所注册。根据眼底照片对MMD进行分级。扫描源OCT(SS-OCT)和OCTA进行脉络膜层厚度(CT)和脉络膜血管(脉络膜血管密度(CVD),脉络膜分支面积（CBA）和平均脉络膜血管宽度（MCVW））在不同脉络膜层（整体脉络膜层（CL），中血管脉络膜层（MVCL），大血管脉络膜层（LVCL））。
■CTCL（r=-0.58，p<0.001），CTMVCL（r=-0.22，p=0.04），MCVWCL（r=-0.58，p<0.001），CVDCL(r=-0.19,p=0.02)与AL呈负相关,而CBACL呈正相关(r=0.61,p<0.001)。与没有MMD的眼睛相比，患有MMD2的眼睛CTCL较低（120.37±47.18µmvs218.33±92.70µm，p<0.001)，CTMVCL(70.57±15.28µmvs85.32±23.71µm,p=0.04),CTLVCL(101.65±25.36µmvs154.55±68.41µm,p=0.001）和更大的CVDCL（71.10±3.97％vs66.97±3.63％，p<0.001)，CVDMVCL（66.96±2.35%vs65.06±2.69%，p=0.002),CVDLVCL（68.36±2.56%vs66.58±2.88%，p=0.012),MCVWMVCL(6.14±0.34µmvs5.90±0.35µm,p=0.007),和CBACL（12.69±1.38%vs11.34±1.18%，p<0.001)。在调整了年龄之后,厚CTCL(比值比(OR)0.98，95%置信区间(CI)0.97-0.99，p<0.001)，CTMVCL（OR0.97（0.94-0.99），p=0.002）和CTLVCL（OR0.97（0.96-0.98，p<0.001）与MMD2的较低几率显着相关，而CVDCL增加（OR1.37（1.20-1.55），p<0.001)，CVDMVCL（OR1.39（1.12-1.73），p=0.003),CVDLVCL（OR1.31（1.07-1.60），p=0.009),CBACL（或2.19（1.55-3.08），p<0.001)和MCVWMVCL(OR6.97(1.59-30.51)，p=0.01）与MMD2的较高几率显着相关。
■脉络膜血管宽度减小，密度和厚度，在长AL眼中观察到血管分支增加。脉络膜更薄、更密，分支面积和血管宽度更大，这些都可能是缺氧的迹象，与MMD2的更大几率相关。
