PDF(Pubmed)
Abstract：
Craniosynostosis (CS) or the premature fusion of one or more cranial sutures in utero, or during the first years of life, can present in isolation or as a multisystem clinical disorder with a particular impact on visual function. Among ophthalmic complications, optic neuropathy is a significant cause of irreversible vision loss in these patients. Children with CS are at higher risk of developing elevated intracranial pressure which can lead to papilledema and, ultimately, optic atrophy. In addition, sometimes associated obstructive sleep apnea, abnormalities in central nervous system venous development, and Chiari malformation may contribute to optic neuropathy. Ophthalmologists have an important role in managing a number of coexistent ophthalmologic complications such as strabismus, anisometropia, amblyopia, ptosis, and exposure keratopathy in addition to maintaining surveillance for early signs of optic neuropathy; they play a critical consultative role contributing to the decision for primary or repeat decompressive surgery. In this article, we aim to review the etiology, diagnostic approach, and management of optic neuropathies in patients with craniosynostosis.
摘要：
颅骨融合（CS）或子宫内一条或多条颅骨缝线过早融合，或者在生命的最初几年，可以单独存在或作为对视觉功能有特殊影响的多系统临床疾病。在眼科并发症中，视神经病变是这些患者不可逆性视力丧失的重要原因.患有CS的儿童发生颅内压升高的风险较高，这可能导致乳头水肿，最终,视神经萎缩.此外,有时伴有阻塞性睡眠呼吸暂停，中枢神经系统静脉发育异常，Chiari畸形可能导致视神经病变。眼科医生在管理一些共存的眼科并发症，如斜视，屈光参差,弱视,上睑下垂,和暴露性角膜病变，除了维持视神经病变的早期迹象的监测;他们发挥重要的咨询作用，有助于决定原发性或重复减压手术。在这篇文章中,我们的目的是回顾病因，诊断方法，颅骨融合症患者视神经病变的治疗。
