PDF(Pubmed)
Abstract：
Primary open angle glaucoma (POAG) is a progressive and chronic disease exhibiting many of the features of fibrosis. The extracellular matrix (ECM) in the trabecular meshwork (TM) undergoes extensive remodeling and enhanced rigidity, resembling fibrotic changes. In addition, there are changes associated with myofibroblast activation and cell contractility that further drives tissue fibrosis and stiffening. This review discusses what is known about the integrins in the TM and their involvement in fibrotic processes.
摘要：
原发性开角型青光眼（POAG）是一种表现出许多纤维化特征的进行性慢性疾病。小梁网（TM）中的细胞外基质（ECM）经历了广泛的重塑和增强的刚性，类似纤维化的变化。此外,存在与肌成纤维细胞活化和细胞收缩性相关的变化，进一步驱动组织纤维化和硬化。这篇综述讨论了TM中整合素的已知情况及其在纤维化过程中的参与。
