PDF(Pubmed)
Abstract：
UNASSIGNED: Antiretroviral therapy has decreased the prevalence of retinal opportunistic infections in people living with HIV (PLWH). However, abnormalities in visual function are evident and may be associated with an early onset of aging in PLWH. In this study, we examined the Retinal Nerve Fibre Layer (RNFL) thickness and visual function in PLWH and HIV non-infected controls in Malaysia.
UNASSIGNED: Cross-sectional study.
UNASSIGNED: Two hundred and two (202) PLWH without retinal opportunistic infection and 182 age-matched, HIV seronegative individuals were enrolled. PLWH were recruited from the Infectious Disease clinic at the University Malaya Medical Centre. Controls were recruited among the hospital staff and community volunteers. RNFL thickness was measured with spectral domain optical coherence tomography (SDOCT). Visual functions include visual acuity using LogMAR chart and contrast sensitivity using Pelli- Robson Chart.
UNASSIGNED: All PLWH (mean age 46.1 years ± 9.9 years) in the study were on ART and 61.2% had a CD4+ T-cell count more than 500 cell/μl. The mean visual acuity was similar between the two groups (LogMAR 0.05 vs. 0.07, p = 0.115). Contrast sensitivity was lower in PLWH compared to HIV seronegative individuals (1.90 vs 1.93, p = 0.032). RNFL thickness was significantly thinner in the temporal quadrant for PLWH compared to controls (68.89 μm vs 74.08 μm, p = 0.001).
UNASSIGNED: Changes in RNFL thickness and contrast sensitivity were seen in PLWH despite their relatively young age and well controlled HIV disease. The changes reflect structural and functional deficits, and could have long-term implications on their health trajectory.
UNASSIGNED: Cross-sectional study.
UNASSIGNED: Two hundred and two (202) PLWH without retinal opportunistic infection and 182 age-matched, HIV seronegative individuals were enrolled. PLWH were recruited from the Infectious Disease clinic at the University Malaya Medical Centre. Controls were recruited among the hospital staff and community volunteers. RNFL thickness was measured with spectral domain optical coherence tomography (SDOCT). Visual functions include visual acuity using LogMAR chart and contrast sensitivity using Pelli- Robson Chart.
UNASSIGNED: All PLWH (mean age 46.1 years ± 9.9 years) in the study were on ART and 61.2% had a CD4+ T-cell count more than 500 cell/μl. The mean visual acuity was similar between the two groups (LogMAR 0.05 vs. 0.07, p = 0.115). Contrast sensitivity was lower in PLWH compared to HIV seronegative individuals (1.90 vs 1.93, p = 0.032). RNFL thickness was significantly thinner in the temporal quadrant for PLWH compared to controls (68.89 μm vs 74.08 μm, p = 0.001).
UNASSIGNED: Changes in RNFL thickness and contrast sensitivity were seen in PLWH despite their relatively young age and well controlled HIV disease. The changes reflect structural and functional deficits, and could have long-term implications on their health trajectory.
摘要：
抗逆转录病毒疗法降低了HIV感染者（PLWH）中视网膜机会性感染的患病率。然而,视觉功能异常很明显，可能与PLWH的早期衰老有关。在这项研究中,我们检查了马来西亚PLWH和HIV未感染对照的视网膜神经纤维层(RNFL)厚度和视觉功能.
■横断面研究。
■两百两（202）PLWH，无视网膜机会性感染和182个年龄匹配，纳入HIV血清阴性个体。PLWH是从马来亚大学医学中心的传染病诊所招募的。在医院工作人员和社区志愿者中招募了对照。使用谱域光学相干断层扫描(SDOCT)测量RNFL厚度。视觉功能包括使用LogMAR图的视敏度和使用Pelli-Robson图的对比敏感度。
■研究中的所有PLWH（平均年龄46.1岁±9.9岁）均接受ART治疗，61.2％的CD4T细胞计数超过500个细胞/μl。两组的平均视力相似(LogMAR0.05vs.0.07,p=0.115)。与HIV血清阴性个体相比，PLWH的对比敏感度较低（1.90vs1.93，p=0.032）。与对照组相比，PLWH的时间象限的RNFL厚度显着变薄（68.89μmvs74.08μm，p=0.001)。
■尽管年龄相对较小并且HIV疾病得到了很好的控制，但在PLWH中仍观察到RNFL厚度和对比敏感度的变化。这些变化反映了结构和功能缺陷，并可能对他们的健康轨迹产生长期影响。
■横断面研究。
■两百两（202）PLWH，无视网膜机会性感染和182个年龄匹配，纳入HIV血清阴性个体。PLWH是从马来亚大学医学中心的传染病诊所招募的。在医院工作人员和社区志愿者中招募了对照。使用谱域光学相干断层扫描(SDOCT)测量RNFL厚度。视觉功能包括使用LogMAR图的视敏度和使用Pelli-Robson图的对比敏感度。
■研究中的所有PLWH（平均年龄46.1岁±9.9岁）均接受ART治疗，61.2％的CD4T细胞计数超过500个细胞/μl。两组的平均视力相似(LogMAR0.05vs.0.07,p=0.115)。与HIV血清阴性个体相比，PLWH的对比敏感度较低（1.90vs1.93，p=0.032）。与对照组相比，PLWH的时间象限的RNFL厚度显着变薄（68.89μmvs74.08μm，p=0.001)。
■尽管年龄相对较小并且HIV疾病得到了很好的控制，但在PLWH中仍观察到RNFL厚度和对比敏感度的变化。这些变化反映了结构和功能缺陷，并可能对他们的健康轨迹产生长期影响。
