PDF(Pubmed)
Abstract：
UNASSIGNED: Around one in forty patients are diagnosed with optic disc drusen (ODD) during their lifetime. Complications of these acellular deposits range from asymptomatic visual field deficits to artery occlusion and subsequent cecity. Still, the pathogenesis of their emergence remains controversial. In particular, it was suggested 50 years ago that a narrow disc and scleral canal is one factor leading to axoplasmic flow disturbance, which induces ODD formation. However, this hypothesis is still debated today. To evaluate the basis of this theory, we will conduct a systematic review and meta-analysis of studies evaluating the scleral canal size in patients with ODD and in healthy subjects.
UNASSIGNED: We will search MEDLINE via PubMed, Cochrane, and EMBASE electronic databases to identify articles published before November 29, 2022 that measure the scleral canal size in patients with ODD and in healthy subjects. In addition, grey literature will be searched. The meta-analysis will include studies that include patients with a clinical or imaging diagnosis of ODD and healthy subjects. Additionally, we will perform a subgroup analysis to compare patients with buried ODD and patients with visible ODD. Extracted data from included studies will be presented descriptively, and effect sizes will be computed based on the recommendations from the Cochrane Collaboration handbook.
UNASSIGNED: The hypothesis that a narrow scleral canal is a risk factor of ODD has long been debated and this systematic review and meta-analysis should disentangle the different views. Understanding the underlying factors driving the development of ODD should help us focus on patients at risk and develop strategies to prevent advanced stages of the disease in these patients. Besides, focusing on patients with small scleral canals should help us derive associated factors and provide a better understanding of the pathology.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022375110.
UNASSIGNED: We will search MEDLINE via PubMed, Cochrane, and EMBASE electronic databases to identify articles published before November 29, 2022 that measure the scleral canal size in patients with ODD and in healthy subjects. In addition, grey literature will be searched. The meta-analysis will include studies that include patients with a clinical or imaging diagnosis of ODD and healthy subjects. Additionally, we will perform a subgroup analysis to compare patients with buried ODD and patients with visible ODD. Extracted data from included studies will be presented descriptively, and effect sizes will be computed based on the recommendations from the Cochrane Collaboration handbook.
UNASSIGNED: The hypothesis that a narrow scleral canal is a risk factor of ODD has long been debated and this systematic review and meta-analysis should disentangle the different views. Understanding the underlying factors driving the development of ODD should help us focus on patients at risk and develop strategies to prevent advanced stages of the disease in these patients. Besides, focusing on patients with small scleral canals should help us derive associated factors and provide a better understanding of the pathology.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022375110.
摘要：
■大约每40名患者中就有1名在其一生中被诊断为视盘玻璃疣（ODD）。这些无细胞沉积物的并发症范围从无症状的视野缺损到动脉闭塞和随后的盲孔。尽管如此，其出现的发病机制仍存在争议。特别是,50年前有人提出，狭窄的椎间盘和巩膜管是导致轴浆血流紊乱的一个因素，诱导奇数形成。然而,这一假设今天仍在争论中。为了评价这一理论的基础，我们将对评估ODD患者和健康受试者巩膜管大小的研究进行系统评价和荟萃分析.
■我们将通过PubMed搜索MEDLINE，科克伦,和EMBASE电子数据库，以确定2022年11月29日之前发表的测量ODD患者和健康受试者巩膜管大小的文章。此外,灰色文献将被搜索。荟萃分析将包括临床或影像学诊断为ODD的患者和健康受试者的研究。此外,我们将进行亚组分析,比较隐埋ODD患者和可见ODD患者.纳入研究的提取数据将以描述性方式呈现，和效果大小将根据Cochrane协作手册中的建议进行计算。
■巩膜管窄是ODD的危险因素的假设长期以来一直存在争议，本系统评价和荟萃分析应解决不同的观点。了解驱动ODD发展的潜在因素应该有助于我们关注处于危险中的患者，并制定策略来预防这些患者的疾病晚期。此外,关注小巩膜管患者应该有助于我们得出相关因素，并更好地了解病理。
■https://www.crd.约克。AC.uk/prospro/display_record.php?ID=CRD42022375110。
■我们将通过PubMed搜索MEDLINE，科克伦,和EMBASE电子数据库，以确定2022年11月29日之前发表的测量ODD患者和健康受试者巩膜管大小的文章。此外,灰色文献将被搜索。荟萃分析将包括临床或影像学诊断为ODD的患者和健康受试者的研究。此外,我们将进行亚组分析,比较隐埋ODD患者和可见ODD患者.纳入研究的提取数据将以描述性方式呈现，和效果大小将根据Cochrane协作手册中的建议进行计算。
■巩膜管窄是ODD的危险因素的假设长期以来一直存在争议，本系统评价和荟萃分析应解决不同的观点。了解驱动ODD发展的潜在因素应该有助于我们关注处于危险中的患者，并制定策略来预防这些患者的疾病晚期。此外,关注小巩膜管患者应该有助于我们得出相关因素，并更好地了解病理。
■https://www.crd.约克。AC.uk/prospro/display_record.php?ID=CRD42022375110。
