PDF(Pubmed)
Abstract：
The Warburg effect, which was first described a century ago, asserts that mitotic tumor cells generate higher quantities of lactate. Intriguingly, even in typical physiological circumstances, postmitotic retinal photoreceptor cells also produce elevated levels of lactate. Initially classified as metabolic waste, lactate has since gained recognition as a significant intracellular signaling mediator and extracellular ligand. This current review endeavors to provide a concise overview and discourse on the following topics: the localization of lactate-producing enzymes, the functional significance of these enzymes, the signaling functions of lactate, and its impact on the gene expression of photoreceptors in retinal cells.
摘要：
Warburg效应,这是一个世纪前首次描述的，断言有丝分裂肿瘤细胞产生更多的乳酸。有趣的是，即使在典型的生理环境中，有丝分裂后的视网膜感光细胞也产生升高的乳酸水平。最初被归类为代谢废物，乳酸已被公认为重要的细胞内信号传递介质和细胞外配体。本综述致力于提供以下主题的简明概述和论述：乳酸产生酶的定位，这些酶的功能意义，乳酸的信号功能，及其对视网膜细胞光感受器基因表达的影响。
