PDF(Pubmed)
Abstract：
UNASSIGNED: Scleritis represents a severe extra-articular manifestation of rheumatoid arthritis (RA). Recent clinical observations suggest a decreasing incidence of scleritis in RA, attributed to improved treatment options. Our study reports on the incidence and clinical characteristics of scleritis in RA observed in the biological era and reflects on our results in a historical perspective.
UNASSIGNED: We performed a retrospective evaluation of all 1623 consecutive patients with RA diagnosed at the department of rheumatology between 2011 and 2021 at the Erasmus Medical Center to investigate the incidence of scleritis. We also reviewed clinical and laboratory data of all patients with scleritis and RA from the department of ophthalmology at our center. In addition, we reviewed the literature on this topic and discuss our results in view of changes over time.
UNASSIGNED: The incidence of scleritis within recent series of patients with a diagnosis of RA in our tertiary center was 0,25% in 10 years (4 out of 1623; 2011-2021).The cumulative incidence of scleritis in RA based on literature review from the pre-biologic era varied from 0.7% per 8 years to 0,8% per 30 years. Manifestations and complications of scleritis remained unchanged over time, with scleral necrosis developing in more than 80% of cases and mortality of RA patients with scleritis remained similar to pre-biologic era (30% in 9 years after the onset of scleritis). The RA patients with scleritis often exhibited autoantibodies (rheumatoid factor and/or anti-citrullinated protein antibody) and erosive disease.
UNASSIGNED: Although our recent series is characterized by a slightly lower incidence of scleritis in RA compared to the pre-biologic era, clinical presentation remained severe and similar to the pre-biologic era. Ophthalmologists and rheumatologists should be aware of scleritis as a severe extra-articular manifestation of RA.
UNASSIGNED: We performed a retrospective evaluation of all 1623 consecutive patients with RA diagnosed at the department of rheumatology between 2011 and 2021 at the Erasmus Medical Center to investigate the incidence of scleritis. We also reviewed clinical and laboratory data of all patients with scleritis and RA from the department of ophthalmology at our center. In addition, we reviewed the literature on this topic and discuss our results in view of changes over time.
UNASSIGNED: The incidence of scleritis within recent series of patients with a diagnosis of RA in our tertiary center was 0,25% in 10 years (4 out of 1623; 2011-2021).The cumulative incidence of scleritis in RA based on literature review from the pre-biologic era varied from 0.7% per 8 years to 0,8% per 30 years. Manifestations and complications of scleritis remained unchanged over time, with scleral necrosis developing in more than 80% of cases and mortality of RA patients with scleritis remained similar to pre-biologic era (30% in 9 years after the onset of scleritis). The RA patients with scleritis often exhibited autoantibodies (rheumatoid factor and/or anti-citrullinated protein antibody) and erosive disease.
UNASSIGNED: Although our recent series is characterized by a slightly lower incidence of scleritis in RA compared to the pre-biologic era, clinical presentation remained severe and similar to the pre-biologic era. Ophthalmologists and rheumatologists should be aware of scleritis as a severe extra-articular manifestation of RA.
摘要：
■巩膜炎代表类风湿性关节炎（RA）的严重关节外表现。最近的临床观察表明，RA中巩膜炎的发病率下降，归因于改进的治疗选择。我们的研究报告了生物学时代观察到的RA巩膜炎的发生率和临床特征，并从历史角度反映了我们的结果。
■我们对伊拉斯谟医学中心2011年至2021年间在风湿病科诊断的所有1623例连续RA患者进行了回顾性评估，以调查巩膜炎的发生率。我们还审查了我们中心眼科所有巩膜炎和RA患者的临床和实验室数据。此外,我们回顾了有关该主题的文献，并讨论了我们的结果随着时间的变化。
■在我们的三级中心最近一系列诊断为RA的患者中，巩膜炎的发病率在10年内为0.25%（1623人中有4人；2011-2021年）。根据生物学前期的文献综述，RA中巩膜炎的累积发病率从每8年0.7％到每30年0.8％不等。巩膜炎的表现和并发症随着时间的推移保持不变，超过80%的病例出现巩膜坏死,RA患者巩膜炎的死亡率与生物前期相似(巩膜炎发病后9年内为30%).患有巩膜炎的RA患者通常表现出自身抗体（类风湿因子和/或抗瓜氨酸化蛋白抗体）和糜烂疾病。
■尽管我们最近的系列的特点是与前生物时代相比，RA中巩膜炎的发病率略低，临床表现仍然严重,与生物学前期相似.眼科医生和风湿病学家应该意识到巩膜炎是RA的严重关节外表现。
■我们对伊拉斯谟医学中心2011年至2021年间在风湿病科诊断的所有1623例连续RA患者进行了回顾性评估，以调查巩膜炎的发生率。我们还审查了我们中心眼科所有巩膜炎和RA患者的临床和实验室数据。此外,我们回顾了有关该主题的文献，并讨论了我们的结果随着时间的变化。
■在我们的三级中心最近一系列诊断为RA的患者中，巩膜炎的发病率在10年内为0.25%（1623人中有4人；2011-2021年）。根据生物学前期的文献综述，RA中巩膜炎的累积发病率从每8年0.7％到每30年0.8％不等。巩膜炎的表现和并发症随着时间的推移保持不变，超过80%的病例出现巩膜坏死,RA患者巩膜炎的死亡率与生物前期相似(巩膜炎发病后9年内为30%).患有巩膜炎的RA患者通常表现出自身抗体（类风湿因子和/或抗瓜氨酸化蛋白抗体）和糜烂疾病。
■尽管我们最近的系列的特点是与前生物时代相比，RA中巩膜炎的发病率略低，临床表现仍然严重,与生物学前期相似.眼科医生和风湿病学家应该意识到巩膜炎是RA的严重关节外表现。
