PDF(Pubmed)
Abstract：
UNASSIGNED: Thyroid hormones (THs) have been found that it is closely associated with the onset and progression of non-alcoholic fatty liver disease (NAFLD). However, the current study could not verify the intrinsic relationship between thyroid hormones and NAFLD, which requires further research.
UNASSIGNED: The searches of studies reported both TH level in serum and NAFLD were performed in PubMed, Web of Science, Cochrane Library, and Embase databases. We combined an overall meta-analysis with a dose-response meta-analysis to assess the correlation and dose-response relationship between thyroid function levels and the risk of NAFLD.
UNASSIGNED: Overall, 10 studies were included with a total of 38,425 individuals. We found that the non-linear dose-response model showed that for every 1 ng/dL increase in FT4, the risk of NAFLD was reduced by 10.56% (p=0.003). The odds ratios (ORs) for NAFLD with high free triiodothyronine (FT3) exposure compared to those with low FT3 were 1.580 (95% CI 1.370 to 1.830, I2 = 0.0%, p<0.001) in the overall meta-analysis. The continuous variable meta-analysis indicated that individuals with high levels of TSH (SMD=1.32, 95% CI 0.660 to 1.970, p<0.001) had significantly higher levels of liver fibrosis than those with low levels.
UNASSIGNED: Our findings only validate that there is a correlation between the occurrence of NAFLD and abnormal levels of THs, and it is expected that more observational studies will still be conducted in the future to further demonstrate the relationship between thyroid hormones and NAFLD.
UNASSIGNED: Registered number in PROSPERO: CRD42023405052.
UNASSIGNED: The searches of studies reported both TH level in serum and NAFLD were performed in PubMed, Web of Science, Cochrane Library, and Embase databases. We combined an overall meta-analysis with a dose-response meta-analysis to assess the correlation and dose-response relationship between thyroid function levels and the risk of NAFLD.
UNASSIGNED: Overall, 10 studies were included with a total of 38,425 individuals. We found that the non-linear dose-response model showed that for every 1 ng/dL increase in FT4, the risk of NAFLD was reduced by 10.56% (p=0.003). The odds ratios (ORs) for NAFLD with high free triiodothyronine (FT3) exposure compared to those with low FT3 were 1.580 (95% CI 1.370 to 1.830, I2 = 0.0%, p<0.001) in the overall meta-analysis. The continuous variable meta-analysis indicated that individuals with high levels of TSH (SMD=1.32, 95% CI 0.660 to 1.970, p<0.001) had significantly higher levels of liver fibrosis than those with low levels.
UNASSIGNED: Our findings only validate that there is a correlation between the occurrence of NAFLD and abnormal levels of THs, and it is expected that more observational studies will still be conducted in the future to further demonstrate the relationship between thyroid hormones and NAFLD.
UNASSIGNED: Registered number in PROSPERO: CRD42023405052.
摘要：
■已发现甲状腺激素（THs）与非酒精性脂肪性肝病（NAFLD）的发病和进展密切相关。然而,目前的研究无法验证甲状腺激素和NAFLD之间的内在关系，这需要进一步的研究。
■在PubMed，WebofScience,科克伦图书馆,和Embase数据库。我们将总体荟萃分析与剂量反应荟萃分析相结合，以评估甲状腺功能水平与NAFLD风险之间的相关性和剂量反应关系。
■总的来说，共纳入10项研究，共38,425人。我们发现，非线性剂量反应模型显示，FT4中每增加1ng/dL，NAFLD的风险降低10.56％（p=0.003）。与低FT3相比，高游离三碘甲状腺原氨酸（FT3）暴露的NAFLD的比值比（ORs）为1.580（95％CI1.370至1.830，I2=0.0％，p<0.001)在整体荟萃分析中。连续变量荟萃分析表明，TSH水平高（SMD=1.32，95％CI0.660至1.970，p<0.001）的个体肝纤维化水平明显高于低水平的个体。
■我们的发现仅验证了NAFLD的发生与THs异常水平之间存在相关性，预计未来仍将进行更多的观察性研究，以进一步证明甲状腺激素与NAFLD之间的关系。
■PROSPERO中的注册号：CRD42023405052。
■在PubMed，WebofScience,科克伦图书馆,和Embase数据库。我们将总体荟萃分析与剂量反应荟萃分析相结合，以评估甲状腺功能水平与NAFLD风险之间的相关性和剂量反应关系。
■总的来说，共纳入10项研究，共38,425人。我们发现，非线性剂量反应模型显示，FT4中每增加1ng/dL，NAFLD的风险降低10.56％（p=0.003）。与低FT3相比，高游离三碘甲状腺原氨酸（FT3）暴露的NAFLD的比值比（ORs）为1.580（95％CI1.370至1.830，I2=0.0％，p<0.001)在整体荟萃分析中。连续变量荟萃分析表明，TSH水平高（SMD=1.32，95％CI0.660至1.970，p<0.001）的个体肝纤维化水平明显高于低水平的个体。
■我们的发现仅验证了NAFLD的发生与THs异常水平之间存在相关性，预计未来仍将进行更多的观察性研究，以进一步证明甲状腺激素与NAFLD之间的关系。
■PROSPERO中的注册号：CRD42023405052。
