关键词: meta-analysis metabolic component metabolic syndrome subclinical hypothyroidism thyroid

Mesh : Humans Metabolic Syndrome / epidemiology complications Hypothyroidism / complications epidemiology Risk Factors

来  源:   DOI:10.3389/fendo.2024.1399236   PDF(Pubmed)

Abstract:
UNASSIGNED: Subclinical hypothyroidism (SCH) is a common endocrine subclinical disorder, the main adverse consequences of which are the development of clinical hypothyroidism and the promotion of ischemic heart disease. Metabolic syndrome (MetS) is a collection of metabolic problems. The goal of this meta-analysis was to evaluate the relationship between MetS and SCH.
UNASSIGNED: Suitable publications were identified using PubMed, Embase, and the Cochrane Library. The meta-analysis included only studies in English that reported odds ratio (OR) data for MetS and SCH. Two researchers combined data using a random-effects model. OR and 95% confidence intervals (CIs) were used to present the results.
UNASSIGNED: MetS was associated with an elevated risk of developing SCH (OR 2.56, 95% CI 1.44-4.55). However, the individual components of MetS were not associated with the risk of SCH. Subgroup analysis revealed that different definitions of MetS had varying effects on SCH. Sensitivity analysis confirmed that our results were robust.
UNASSIGNED: This meta-analysis indicates that patients with MetS have an increased risk of SCH, while there is no significant association between the five individual components of MetS and the risk of SCH.
UNASSIGNED: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023454415.
摘要:
亚临床甲状腺功能减退症(SCH)是一种常见的内分泌亚临床疾病,其主要不良后果是临床甲状腺功能减退症的发展和缺血性心脏病的促进。代谢综合征(MetS)是代谢问题的集合。这项荟萃分析的目的是评估MetS和SCH之间的关系。
使用PubMed确定了合适的出版物,Embase,还有Cochrane图书馆.荟萃分析仅包括英文研究,这些研究报告了MetS和SCH的比值比(OR)数据。两名研究人员使用随机效应模型组合数据。使用OR和95%置信区间(CI)来呈现结果。
MetS与发生SCH的风险升高相关(OR2.56,95%CI1.44-4.55)。然而,MetS的各个组成部分与SCH的风险无关.亚组分析显示,MetS的不同定义对SCH有不同的影响。敏感性分析证实我们的结果是稳健的。
这项荟萃分析表明,患有MetS的患者发生SCH的风险增加,而MetS的五个单独成分与SCH的风险之间没有显着关联。
https://www.crd.约克。AC.英国/PROSPERO/,标识符CRD42023454415。
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