Abstract：
The cyclic GMP-AMP synthase (cGAS), a prominent intracellular DNA sensor in mammalian cells, controls the innate immune response and the stimulator of interferon genes (STING)-mediated synthesis of pro-inflammatory cytokines, such as type-I interferon (IFN-I). For decades, IFN-I has been hypothesized to be essential in the development of systemic lupus erythematosus (SLE), a chronic multisystem autoimmunity characterized by immune complex (IC) deposition in small vessels. Recent findings revealed that the activation of the cGAS-STING pathway by self-DNA would propagate the autoimmune responses via upregulating IFN-I production in SLE. In this review, we aimed to provide a comprehensive outlook of the role of the cGAS-STING pathway in SLE pathobiology, as well as, a better understanding of current therapeutic opportunities targeting this axis.
摘要：
环GMP-AMP合酶（cGAS），哺乳动物细胞中一个突出的细胞内DNA传感器，控制先天免疫反应和干扰素基因（STING）介导的促炎细胞因子合成的刺激物，例如I型干扰素(IFN-I)。几十年来,IFN-I被认为在系统性红斑狼疮（SLE）的发展中至关重要，一种慢性多系统自身免疫，其特征是免疫复合物（IC）沉积在小血管中。最近的发现表明，自身DNA对cGAS-STING途径的激活将通过上调SLE中IFN-I的产生来传播自身免疫反应。在这次审查中,我们旨在全面展望cGAS-STING通路在SLE病理生物学中的作用，还有,更好地了解当前针对此轴的治疗机会。
