METHODS: A retrospective study between 1990 and 2007 was conducted. The medical records and tissue samples of patients with urothelial bladder tumours were reviewed, and patients with a first diagnosis of urothelial carcinoma of the bladder at age 40 years or younger were selected. Their clinical and pathological data and disease-free survival were analysed.
RESULTS: This study included 43 patients, with a median follow-up of 152 months (interquartile range (IQR): 96-222) and a mean age at diagnosis of 34 years (SD: 4.6). Thirty-five patients (81.4%) had non-muscle invasive tumours at diagnosis, and 53.5%, 27.9% and 18.6% had tumour grades of G1, G2 and G3, respectively. Fifteen patients (34.9%) experienced recurrence, and eight (18.6%) progressed. At 24 and 60 months, the recurrence-free survival rates were 84.8% (95% confidence interval (CI): 69.2%-92.9%) and 68.9% (95% CI: 51.7%-81%), respectively, and the progression-free survival rates were 94.9% (95% CI: 81%-98.7%) and 92.2% (95% CI: 77.8%-97.4%), respectively.
CONCLUSIONS: Bladder cancer is an uncommon disease in young patients. In most cases, it consists of non-muscle-invasive tumours, with a low rate of recurrence and progression. The prognosis is based on the tumour\'s characteristics and not on the patient\'s age.
方法:在1990年至2007年间进行了一项回顾性研究。回顾了膀胱尿路上皮肿瘤患者的医疗记录和组织样本,选择年龄在40岁或以下的首次诊断为膀胱尿路上皮癌的患者。分析患者的临床病理资料和无病生存期。
结果:本研究包括43名患者,中位随访时间为152个月(四分位距(IQR):96-222),诊断平均年龄为34岁(SD:4.6)。35例患者(81.4%)在诊断时患有非肌肉浸润性肿瘤,53.5%,27.9%和18.6%的肿瘤分级分别为G1、G2和G3。15例患者(34.9%)复发,八人(18.6%)进步。在24个月和60个月时,无复发生存率分别为84.8%(95%置信区间(CI):69.2%-92.9%)和68.9%(95%CI:51.7%-81%),分别,无进展生存率分别为94.9%(95%CI:81%-98.7%)和92.2%(95%CI:77.8%-97.4%),分别。
结论:膀胱癌在年轻患者中是一种少见的疾病。在大多数情况下,它由非肌肉侵袭性肿瘤组成,复发和进展率低。预后是基于肿瘤的特征而不是患者的年龄。