Abstract:
Aim: Torquetenovirus (TTV) was a promising biomarker for immunity, while lung regional TTV for evaluating the opportunistic infection among immunocompromised hosts (ICH) was unclear. Materials & methods: In the ICH and non-ICH populations, we compared the susceptibility to opportunistic infections, clinical severity and the prognosis between subgroups, respectively. Results: ICH with detectable bronchoalveolar lavage fluid (BALF)-TTV were more susceptible to lung aspergillosis and Mycobacterium infections. Furthermore, our data demonstrated that the ICH cohort with detectable BALF-TTV represented a higher clinical severity and a worse prognosis, while the above findings were not found in the non-ICH population. Conclusion: Our findings demonstrated that the BALF-TTV could act as an effective predictor for opportunistic infection for ICH that complemented the CD4+ T cell counts.
[Box: see text].
摘要:
目的:Torquetenovirus(TTV)是一种有前途的免疫生物标志物,而用于评估免疫受损宿主(ICH)机会性感染的肺部区域TTV尚不清楚。材料与方法:在ICH和非ICH人群中,我们比较了机会性感染的易感性,临床严重程度和亚组之间的预后,分别。结果:具有可检测的支气管肺泡灌洗液(BALF)-TTV的ICH更容易受到肺曲霉病和分枝杆菌感染的影响。此外,我们的数据表明,具有可检测BALF-TTV的ICH队列代表更高的临床严重程度和更差的预后,而上述发现未在非ICH人群中发现。结论:我们的发现表明,BALF-TTV可以作为ICH机会性感染的有效预测因子,补充CD4T细胞计数。
[方框:见正文]。