Abstract：
Aim: Torquetenovirus (TTV) was a promising biomarker for immunity, while lung regional TTV for evaluating the opportunistic infection among immunocompromised hosts (ICH) was unclear. Materials & methods: In the ICH and non-ICH populations, we compared the susceptibility to opportunistic infections, clinical severity and the prognosis between subgroups, respectively. Results: ICH with detectable bronchoalveolar lavage fluid (BALF)-TTV were more susceptible to lung aspergillosis and Mycobacterium infections. Furthermore, our data demonstrated that the ICH cohort with detectable BALF-TTV represented a higher clinical severity and a worse prognosis, while the above findings were not found in the non-ICH population. Conclusion: Our findings demonstrated that the BALF-TTV could act as an effective predictor for opportunistic infection for ICH that complemented the CD4+ T cell counts.
[Box: see text].
[Box: see text].
摘要：
目的：Torquetenovirus（TTV）是一种有前途的免疫生物标志物，而用于评估免疫受损宿主（ICH）机会性感染的肺部区域TTV尚不清楚。材料与方法：在ICH和非ICH人群中，我们比较了机会性感染的易感性，临床严重程度和亚组之间的预后，分别。结果：具有可检测的支气管肺泡灌洗液（BALF）-TTV的ICH更容易受到肺曲霉病和分枝杆菌感染的影响。此外，我们的数据表明，具有可检测BALF-TTV的ICH队列代表更高的临床严重程度和更差的预后，而上述发现未在非ICH人群中发现。结论：我们的发现表明，BALF-TTV可以作为ICH机会性感染的有效预测因子，补充CD4T细胞计数。
[方框：见正文]。
[方框：见正文]。
