Abstract：
Objective: The aim of this study was to examine the serum antibody levels against pertussis toxin (PT) in children experiencing an acute asthma attack and to explore the potential association between these levels and asthma. Methods: A prospective investigation was conducted, which involved 107 children with acute asthma attacks and 77 children diagnosed with bronchitis. The serum immunoglobulin G (IgG) antibody levels specific to PT were measured by using an in-house enzyme-linked immunosorbent assay. Based on the serum PT-IgG antibody levels, the children with asthma were categorized into three groups: non-pertussis infected, suspected pertussis infected, and recent pertussis infected. The clinical manifestations and pulmonary function of pediatric patients diagnosed with asthma were assessed and compared across various groups. Results: Of the total asthma group, 25 patients tested positive for PT-IgG, whereas only six patients in the bronchitis group were PT-IgG positive. The prevalence of recent pertussis infection was observed to be higher in the asthma group compared with the bronchitis group. Within the asthma group, those with recent pertussis infection exhibited a higher likelihood of experiencing wheezing and impaired lung function in comparison with the non-pertussis infection group. Conclusion: Pertussis infection is relatively common in children with asthma and correlates with the severity of asthma.
摘要：
目的：本研究的目的是检查急性哮喘发作儿童的血清抗百日咳毒素（PT）抗体水平，并探讨这些水平与哮喘之间的潜在关联。方法:进行前瞻性调查,其中涉及107名急性哮喘发作儿童和77名被诊断患有支气管炎的儿童。通过使用内部酶联免疫吸附测定法测量PT特异性的血清免疫球蛋白G（IgG）抗体水平。根据血清PT-IgG抗体水平，哮喘患儿分为三组：非百日咳感染，疑似百日咳感染,最近百日咳感染。评估并比较各组诊断为哮喘的儿科患者的临床表现和肺功能。结果：在总哮喘组中，25例患者PT-IgG检测呈阳性,而支气管炎组只有6例PT-IgG阳性.与支气管炎组相比，哮喘组近期百日咳感染的患病率更高。在哮喘组中，与非百日咳感染组相比,近期百日咳感染组出现喘息和肺功能受损的可能性更高.结论:百日咳感染在哮喘患儿中较为常见,且与哮喘的严重程度相关。
