PDF(Pubmed)
Abstract：
BACKGROUND: Diabetic foot ulcers (DFU) are a costly complication of diabetes mellitus (DM), with significant implications for the patient and the healthcare professionals that treat them. The primary objective of this study was to evaluate if there were improved healing rates in patients with a DFU that were taking a statin medication compared to those patients with a DFU who were not taking a statin medication. Secondary outcomes assessed were correlations with wound healing or statin use on data obtained from retrospective chart review.
METHODS: A case-control series was performed to obtain appropriate demographic information, comorbid conditions, laboratory values, and physical examination findings. From the time of presentation with DFU, these patients were followed for 12 weeks to evaluate for healing. Healing was defined as full epithelialization of the DFU with no further drainage. Wound healing and statin use correlation testing was then done for collected variables and each cohort. Chi square and Pearson correlation were then performed to identify any significant correlations. All p-values were two-sided, and findings were considered statistically significant at p < 0.05.
RESULTS: Our study identified 109 patients, 75 patients with a DFU on statin medication and 34 patients with a DFU not on statin medication. The statin cohort was more likely to be older, less than 5-year duration of diabetes, have more comorbidities, decreased low-density lipoprotein (LDL) cholesterol, and decreased total cholesterol (p < 0.05). Among those patients taking a statin medication, 48.0% (36/75) healed their DFU within 12 weeks. Among those patients not taking a statin medication, 44.1% (15/34) healed their DFU within 12 weeks. No correlation was noted between wound healing and statin use (p = 0.7). For wound healing, a negative correlation was noted for prior minor amputations (p < 0.05). For statin use, correlations were noted for age, duration of DM, LDL cholesterol level, total cholesterol level, HTN, CAD, and HLD (p < 0.05).
CONCLUSIONS: Statin medication use did not influence DFU healing rates between cohorts. There was a correlation noted between wound healing and prior minor amputations and between statin use and age, duration of DM, LDL cholesterol, total cholesterol, HTN, CAD and HLD. Additionally, we observed no correlation between DFU healing rates and use of a statin medication.
METHODS: A case-control series was performed to obtain appropriate demographic information, comorbid conditions, laboratory values, and physical examination findings. From the time of presentation with DFU, these patients were followed for 12 weeks to evaluate for healing. Healing was defined as full epithelialization of the DFU with no further drainage. Wound healing and statin use correlation testing was then done for collected variables and each cohort. Chi square and Pearson correlation were then performed to identify any significant correlations. All p-values were two-sided, and findings were considered statistically significant at p < 0.05.
RESULTS: Our study identified 109 patients, 75 patients with a DFU on statin medication and 34 patients with a DFU not on statin medication. The statin cohort was more likely to be older, less than 5-year duration of diabetes, have more comorbidities, decreased low-density lipoprotein (LDL) cholesterol, and decreased total cholesterol (p < 0.05). Among those patients taking a statin medication, 48.0% (36/75) healed their DFU within 12 weeks. Among those patients not taking a statin medication, 44.1% (15/34) healed their DFU within 12 weeks. No correlation was noted between wound healing and statin use (p = 0.7). For wound healing, a negative correlation was noted for prior minor amputations (p < 0.05). For statin use, correlations were noted for age, duration of DM, LDL cholesterol level, total cholesterol level, HTN, CAD, and HLD (p < 0.05).
CONCLUSIONS: Statin medication use did not influence DFU healing rates between cohorts. There was a correlation noted between wound healing and prior minor amputations and between statin use and age, duration of DM, LDL cholesterol, total cholesterol, HTN, CAD and HLD. Additionally, we observed no correlation between DFU healing rates and use of a statin medication.
摘要：
背景：糖尿病足溃疡（DFU）是糖尿病（DM）的昂贵并发症，对患者和治疗他们的医疗保健专业人员有重大影响。这项研究的主要目的是评估与未服用他汀类药物的DFU患者相比，服用他汀类药物的DFU患者的治愈率是否提高。评估的次要结果是与伤口愈合或他汀类药物使用相关的回顾性图表审查数据。
方法：进行了病例对照系列以获取适当的人口统计信息，合并症条件，实验室值，和体检结果。从向DFU介绍时开始，对这些患者随访12周,以评估愈合情况.愈合被定义为DFU的完全上皮化，没有进一步的引流。然后对收集的变量和每个队列进行伤口愈合和他汀类药物使用相关性测试。然后进行卡方和皮尔逊相关性以识别任何显著的相关性。所有p值都是双侧的，在p<0.05时，发现被认为具有统计学意义。
结果：我们的研究确定了109名患者，75例服用他汀类药物的DFU患者和34例未服用他汀类药物的DFU患者。他汀类药物队列更有可能年龄较大，糖尿病持续时间少于5年，有更多的合并症，降低低密度脂蛋白（LDL）胆固醇，降低总胆固醇(p<0.05)。在那些服用他汀类药物的患者中，48.0%(36/75)的DFU在12周内愈合。在那些没有服用他汀类药物的患者中，44.1%(15/34)的DFU在12周内愈合。伤口愈合和他汀类药物使用之间没有相关性(p=0.7)。为了伤口愈合，先前的轻微截肢呈负相关(p<0.05).对于他汀类药物的使用，注意到年龄的相关性，DM的持续时间，LDL胆固醇水平，总胆固醇水平,HTN,CAD,和HLD(p<0.05)。
结论：他汀类药物的使用并不影响队列间的DFU治愈率。伤口愈合与先前的小截肢之间以及他汀类药物使用与年龄之间存在相关性，DM的持续时间，LDL胆固醇，总胆固醇,HTN,CAD和HLD。此外,我们观察到DFU治愈率与他汀类药物使用之间没有相关性.
方法：进行了病例对照系列以获取适当的人口统计信息，合并症条件，实验室值，和体检结果。从向DFU介绍时开始，对这些患者随访12周,以评估愈合情况.愈合被定义为DFU的完全上皮化，没有进一步的引流。然后对收集的变量和每个队列进行伤口愈合和他汀类药物使用相关性测试。然后进行卡方和皮尔逊相关性以识别任何显著的相关性。所有p值都是双侧的，在p<0.05时，发现被认为具有统计学意义。
结果：我们的研究确定了109名患者，75例服用他汀类药物的DFU患者和34例未服用他汀类药物的DFU患者。他汀类药物队列更有可能年龄较大，糖尿病持续时间少于5年，有更多的合并症，降低低密度脂蛋白（LDL）胆固醇，降低总胆固醇(p<0.05)。在那些服用他汀类药物的患者中，48.0%(36/75)的DFU在12周内愈合。在那些没有服用他汀类药物的患者中，44.1%(15/34)的DFU在12周内愈合。伤口愈合和他汀类药物使用之间没有相关性(p=0.7)。为了伤口愈合，先前的轻微截肢呈负相关(p<0.05).对于他汀类药物的使用，注意到年龄的相关性，DM的持续时间，LDL胆固醇水平，总胆固醇水平,HTN,CAD,和HLD(p<0.05)。
结论：他汀类药物的使用并不影响队列间的DFU治愈率。伤口愈合与先前的小截肢之间以及他汀类药物使用与年龄之间存在相关性，DM的持续时间，LDL胆固醇，总胆固醇,HTN,CAD和HLD。此外,我们观察到DFU治愈率与他汀类药物使用之间没有相关性.
