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Abstract：
DNA methylation is an important molecular modification that plays a key role in the expression of cancer genes. Evaluation of epigenetic changes, hypomethylation and hypermethylation, in specific genes are applied for cancer diagnosis. Numerous studies have concentrated on describing DNA methylation patterns as biomarkers for cancer diagnosis monitoring and predicting response to cancer therapy. Various techniques for detecting DNA methylation status in cancers are based on sodium bisulfite treatment. According to the application of these methods in research and clinical studies, they have a number of advantages and disadvantages. The current review highlights sodium bisulfite treatment-based techniques, as well as, the advantages, drawbacks, and applications of these methods in the evaluation of human cancers.
摘要：
DNA甲基化是一种重要的分子修饰，在癌基因的表达中起着关键作用。表观遗传变化的评估，低甲基化和超甲基化，在特定的基因应用于癌症诊断。许多研究集中在描述DNA甲基化模式作为癌症诊断监测和预测癌症治疗反应的生物标志物。用于检测癌症中DNA甲基化状态的各种技术基于亚硫酸氢钠治疗。根据这些方法在研究和临床研究中的应用,它们有许多优点和缺点。当前的综述强调了基于亚硫酸氢钠处理的技术，还有,的优势,缺点，以及这些方法在人类癌症评估中的应用。
