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Abstract：
BACKGROUND: Some studies have suggested that uric acid has antioxidant properties that can prevent bone loss, but the relationship between uric acid and bone mineral density is controversial. The aim of this study was to investigate the relationship between UA and BMD in patients with CKD stage 1-3.
METHODS: We extracted 13,047 participants from the NHANES database, including 7342 male subjects and 5705 female subjects. Weighted multiple linear regression analysis was used to investigate the correlation between UA and BMD in patients with CKD stages 1-3.
RESULTS: In patients with CKD stage 1-3, UA was significantly correlated with BMD. In the male group, UA was positively associated with BMD (β, 7.94 [95%CI, 4.95, 10.94]). In the female group, there was a negative relationship between them (β, -5.33 [95%CI, -8.77, -1.89]). The relationship between UA and BMD in male group showed an inverted U-shaped curve, and UA was positively correlated before 6.1 mg/dl and negatively correlated after 6.1 mg/dl. The relationship was basically negative in the female group.
CONCLUSIONS: For the patients with CKD stage 1-3, the relationship between UA and BMD showed an inverted U-shaped curve in the males, while the relationship was largely negative in the females.
METHODS: We extracted 13,047 participants from the NHANES database, including 7342 male subjects and 5705 female subjects. Weighted multiple linear regression analysis was used to investigate the correlation between UA and BMD in patients with CKD stages 1-3.
RESULTS: In patients with CKD stage 1-3, UA was significantly correlated with BMD. In the male group, UA was positively associated with BMD (β, 7.94 [95%CI, 4.95, 10.94]). In the female group, there was a negative relationship between them (β, -5.33 [95%CI, -8.77, -1.89]). The relationship between UA and BMD in male group showed an inverted U-shaped curve, and UA was positively correlated before 6.1 mg/dl and negatively correlated after 6.1 mg/dl. The relationship was basically negative in the female group.
CONCLUSIONS: For the patients with CKD stage 1-3, the relationship between UA and BMD showed an inverted U-shaped curve in the males, while the relationship was largely negative in the females.
摘要：
背景：一些研究表明，尿酸具有抗氧化特性，可以防止骨质流失，但尿酸与骨密度的关系存在争议。这项研究的目的是调查CKD1-3期患者UA与BMD之间的关系。
方法：我们从NHANES数据库中提取了13047名参与者，包括7342名男性受试者和5705名女性受试者。采用加权多元线性回归分析探讨CKD1～3期患者UA与BMD的相关性。
结果：在CKD1-3期患者中，UA与BMD显著相关。在男性群体中，UA与骨密度呈正相关(β，7.94[95CI，4.95，10.94]）。在女性群体中，它们之间存在负相关关系(β，-5.33[95CI，-8.77，-1.89]）。男性组UA与BMD的关系呈倒U型曲线,与UA在6.1mg/dl之前呈正相关，在6.1mg/dl之后呈负相关。在女性群体中，这种关系基本上是负相关的。
结论：对于CKD1-3期患者，UA与BMD之间的关系在男性中呈倒U形曲线，而女性的关系在很大程度上是负面的。
方法：我们从NHANES数据库中提取了13047名参与者，包括7342名男性受试者和5705名女性受试者。采用加权多元线性回归分析探讨CKD1～3期患者UA与BMD的相关性。
结果：在CKD1-3期患者中，UA与BMD显著相关。在男性群体中，UA与骨密度呈正相关(β，7.94[95CI，4.95，10.94]）。在女性群体中，它们之间存在负相关关系(β，-5.33[95CI，-8.77，-1.89]）。男性组UA与BMD的关系呈倒U型曲线,与UA在6.1mg/dl之前呈正相关，在6.1mg/dl之后呈负相关。在女性群体中，这种关系基本上是负相关的。
结论：对于CKD1-3期患者，UA与BMD之间的关系在男性中呈倒U形曲线，而女性的关系在很大程度上是负面的。
