PDF(Pubmed)
Abstract：
The purpose of this study was to investigate the relationship between Inflammatory Prognostic Index (IPI) levels and Contrast-Induced Nephropathy (CIN) risk and postoperative clinical outcomes in patients undergoing coronary angiography (CAG) and/or percutaneous coronary intervention (PCI). A total of 3,340 consecutive patients who underwent CAG and/or PCI between May 2017 and December 2022 were enrolled in this study. Based on their baseline IPI levels, patients were categorized into four groups. Clinical characteristics and postoperative outcomes were compared among these groups. In-hospital outcomes focused on CIN risk, repeated revascularization, major bleeding, and major adverse cardiovascular events (MACEs), while the long-term outcome examined the all-cause readmission rate. Quartile analysis found a significant link between IPI levels and CIN risk, notably in the highest quartile (P < 0.001). Even after adjusting for baseline factors, this association remained significant, with an adjusted Odds Ratio (aOR) of 2.33 (95%CI 1.50-3.64; P = 0.001). Notably, baseline IPI level emerged as an independent predictor of severe arrhythmia, with aOR of 0.50 (95%CI 0.35-0.69; P < 0.001), particularly driven by the highest quartile. Furthermore, a significant correlation between IPI and acute myocardial infarction was observed (P < 0.001), which remained significant post-adjustment. For patients undergoing CAG and/or PCI, baseline IPI levels can independently predict clinical prognosis. As a comprehensive inflammation indicator, IPI effectively identifies high-risk patients post-procedure. This study underscores IPI\'s potential to assist medical professionals in making more precise clinical decisions, ultimately reducing mortality and readmission rates linked to cardiovascular disease (CVD).
摘要：
目的探讨行冠状动脉造影(CAG)和/或经皮冠状动脉介入治疗(PCI)患者炎症预后指数(IPI)水平与对比剂肾病(CIN)风险及术后临床结局的关系。本研究共纳入了2017年5月至2022年12月期间接受CAG和/或PCI的3,340例连续患者。根据他们的基线IPI水平，患者分为四组.比较两组患者的临床特征和术后结局。住院结果集中在CIN风险上，反复血运重建,大出血,和主要不良心血管事件（MACE），而长期结局检查了全因再入院率。四分位数分析发现IPI水平和CIN风险之间存在显著联系，特别是在最高四分位数(P<0.001)。即使在调整了基线因素后，这个协会仍然很重要，调整后的赔率比（aOR）为2.33（95CI1.50-3.64；P=0.001）。值得注意的是,基线IPI水平是严重心律失常的独立预测因子，aOR为0.50（95CI0.35-0.69；P<0.001），特别是由最高四分位数驱动。此外，IPI与急性心肌梗死有显著的相关性(P<0.001),这仍然是很大的工作地点差价调整数。对于接受CAG和/或PCI的患者，基线IPI水平可以独立预测临床预后。作为一个综合性的炎症指标，IPI有效识别术后高危患者。这项研究强调了IPI在帮助医疗专业人员做出更精确的临床决策方面的潜力。最终降低与心血管疾病（CVD）相关的死亡率和再入院率。
