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Abstract：
This study aims to assess the predictive capability of cylindrical Tumor Growth Rate (cTGR) in the prediction of early progression of well-differentiated gastro-entero-pancreatic tumours after Radio Ligand Therapy (RLT), compared to the conventional TGR. Fifty-eight patients were included and three CT scans per patient were collected at baseline, during RLT, and follow-up. RLT response, evaluated at follow-up according to RECIST 1.1, was calculated as a percentage variation of lesion diameters over time (continuous values) and as four different RECIST classes. TGR between baseline and interim CT was computed using both conventional (approximating lesion volume to a sphere) and cylindrical (called cTGR, approximating lesion volume to an elliptical cylinder) formulations. Receiver Operating Characteristic (ROC) curves were employed for Progressive Disease class prediction, revealing that cTGR outperformed conventional TGR (area under the ROC equal to 1.00 and 0.92, respectively). Multivariate analysis confirmed the superiority of cTGR in predicting continuous RLT response, with a higher coefficient for cTGR (1.56) compared to the conventional one (1.45). This study serves as a proof of concept, paving the way for future clinical trials to incorporate cTGR as a valuable tool for assessing RLT response.
摘要：
这项研究旨在评估圆柱形肿瘤生长速率（cTGR）在放射配体治疗（RLT）后高分化胃肠胰腺肿瘤早期进展的预测能力。与传统的TGR相比。纳入58例患者，每个患者在基线时收集3次CT扫描，在RLT期间，和后续行动。RLT响应,在随访时根据RECIST1.1进行评估,计算为病变直径随时间变化的百分比变化(连续值)和四种不同的RECIST类别.基线和中期CT之间的TGR使用常规（接近球形的病变体积）和圆柱形（称为cTGR，将病变体积近似为椭圆柱)配方。受试者工作特征（ROC）曲线用于进行性疾病类别预测，显示cTGR优于常规TGR(ROC下面积分别等于1.00和0.92)。多因素分析证实了cTGR在预测连续RLT反应方面的优越性，与传统的(1.45)相比，cTGR的系数(1.56)更高。这项研究作为概念的证明，为未来的临床试验铺平了道路，将cTGR作为评估RLT反应的有价值的工具。
