Abstract：
OBJECTIVE: Sjögren Syndrome is a systemic autoimmune disorder that presents mainly with sicca symptoms, but frequently affects other body systems which can lead to a wide variety of manifestations. Understanding the neurological and psychiatric manifestations of Sjögren Syndrome can help with an earlier diagnosis of this disease and leads to better clinical outcomes.
RESULTS: We provide an updated overview of the central neurological manifestations, peripheral neurological manifestations and psychiatric manifestations and their diagnosis when associated with primary Sjögren Syndrome. The epidemiology and clinical features of the neurological and psychiatric manifestations are derived from different cohort studies and review articles that were selected from PubMed searches conducted between January 2024 and March 2024. The absence of diagnostic criteria and the scarcity of large, robust studies makes the recognition of the neurological and psychiatric manifestations of Sjögren Syndrome more difficult. Maintaining a high index of suspicion in clinical practice and a close collaboration between the Neurologist and the Rheumatologist will facilitate the diagnosis and management of these patients.
RESULTS: We provide an updated overview of the central neurological manifestations, peripheral neurological manifestations and psychiatric manifestations and their diagnosis when associated with primary Sjögren Syndrome. The epidemiology and clinical features of the neurological and psychiatric manifestations are derived from different cohort studies and review articles that were selected from PubMed searches conducted between January 2024 and March 2024. The absence of diagnostic criteria and the scarcity of large, robust studies makes the recognition of the neurological and psychiatric manifestations of Sjögren Syndrome more difficult. Maintaining a high index of suspicion in clinical practice and a close collaboration between the Neurologist and the Rheumatologist will facilitate the diagnosis and management of these patients.
摘要：
目的：干燥综合征是一种全身性自身免疫性疾病，主要表现为干燥症状，但经常影响其他身体系统，这可能导致各种各样的表现。了解干燥综合征的神经和精神表现可以帮助早期诊断这种疾病，并导致更好的临床结果。
结果：我们提供了中枢神经表现的最新概述，与原发性干燥综合征相关的周围神经表现和精神表现及其诊断。神经和精神病学表现的流行病学和临床特征来自不同的队列研究和评论文章，这些文章是从2024年1月至2024年3月进行的PubMed搜索中选择的。诊断标准的缺乏和大量的稀缺，稳健的研究使得对干燥综合征的神经和精神表现的识别更加困难。在临床实践中保持高度怀疑指数以及神经科医生和风湿病学家之间的密切合作将有助于这些患者的诊断和管理。
结果：我们提供了中枢神经表现的最新概述，与原发性干燥综合征相关的周围神经表现和精神表现及其诊断。神经和精神病学表现的流行病学和临床特征来自不同的队列研究和评论文章，这些文章是从2024年1月至2024年3月进行的PubMed搜索中选择的。诊断标准的缺乏和大量的稀缺，稳健的研究使得对干燥综合征的神经和精神表现的识别更加困难。在临床实践中保持高度怀疑指数以及神经科医生和风湿病学家之间的密切合作将有助于这些患者的诊断和管理。
