Abstract：
UNASSIGNED: Hemophilia is an inherited bleeding disorder. Bleeding, and in particular joint hemorrhage results in chronic arthropathy and disability. Acute and chronic pain are frequent and limit activity and participation and result in decreased health-related quality of life. Remarkable progress has been made in the diagnosis and treatment of hemophilia but bleeding continues to prove recalcitrant to currently available treatments and joint disease remains problematic. Physiotherapy and pain management are mainstays of current multidisciplinary integrated care of people with hemophilia (PWH). The focus of this review is on preservation of joint health in the era of new and innovative therapies.
UNASSIGNED: A search of the PubMed Central was conducted on 1 February 2024 using the MeSH Major Topic terms identified as keywords for the manuscript. This review will highlight what is known and unknown about joint bleeding and arthropathy, including insights on pain as a related complication.
UNASSIGNED: Recent advances in therapeutic interventions aimed at promoting healthy joints in PWH will be discussed, including both the pharmacological treatment landscape and related strategies to promote joint health.
UNASSIGNED: A search of the PubMed Central was conducted on 1 February 2024 using the MeSH Major Topic terms identified as keywords for the manuscript. This review will highlight what is known and unknown about joint bleeding and arthropathy, including insights on pain as a related complication.
UNASSIGNED: Recent advances in therapeutic interventions aimed at promoting healthy joints in PWH will be discussed, including both the pharmacological treatment landscape and related strategies to promote joint health.
摘要：
■血友病是一种遗传性出血性疾病。出血,特别是关节出血会导致慢性关节病和残疾。急性和慢性疼痛是常见的，限制了活动和参与，并导致与健康相关的生活质量下降。在血友病的诊断和治疗方面已经取得了显著的进展,但是出血继续证明对目前可用的治疗是难以抵抗的,并且关节疾病仍然存在问题。物理治疗和疼痛管理是当前血友病（PWH）患者多学科综合护理的支柱。本综述的重点是在新疗法和创新疗法时代保持关节健康。
■对PubMedCentral的搜索于2024年2月1日进行，使用被确定为手稿关键词的MeSH主要主题术语。这篇综述将强调关节出血和关节病的已知和未知，包括对疼痛作为相关并发症的见解。
■将讨论旨在促进PWH健康关节的治疗干预措施的最新进展，包括药物治疗景观和相关策略，以促进联合健康。
■对PubMedCentral的搜索于2024年2月1日进行，使用被确定为手稿关键词的MeSH主要主题术语。这篇综述将强调关节出血和关节病的已知和未知，包括对疼痛作为相关并发症的见解。
■将讨论旨在促进PWH健康关节的治疗干预措施的最新进展，包括药物治疗景观和相关策略，以促进联合健康。
