PDF(Pubmed)
Abstract：
Herpes simplex virus (HSV) encephalitis, predominantly caused by HSV-1, presents with significant morbidity and mortality challenges. This research investigates the particular role of adjunctive corticosteroid therapy in fulminant HSV encephalitis through in-depth analyses of two contrasting cases. Corticosteroids show potential benefits to improve an exaggerated immune response and limit viral dissemination within the brain. Daily assessments and frequent neuroimaging, particularly using magnetic resonance imaging, aid in the management of fulminant cases. Although existing evidence relies on limited case series and retrospective comparisons, the results of the present study emphasize the necessity for large-scale controlled trials to establish definitive guidelines. The discretion of the treating neurologist governs the decision to implement corticosteroids, emphasizing the imperative need for continued research and evidence-based strategies for this challenging neurological condition.
摘要：
单纯疱疹病毒(HSV)脑炎,主要由HSV-1引起，具有显著的发病率和死亡率挑战。本研究通过对两个对比病例的深入分析，探讨了辅助皮质类固醇治疗在暴发性HSV脑炎中的特殊作用。皮质类固醇显示出改善过度免疫反应和限制病毒在大脑内传播的潜在益处。每日评估和频繁的神经成像，特别是使用磁共振成像，协助管理突发案件。尽管现有证据依赖于有限的病例系列和回顾性比较，本研究的结果强调了大规模对照试验建立明确指南的必要性.治疗神经科医生的自由裁量权决定实施皮质类固醇的决定，强调迫切需要对这种具有挑战性的神经系统疾病进行持续研究和循证策略。
