PDF(Pubmed)
Abstract：
Tumefactive demyelinating lesion is a variant of multiple sclerosis that is a diagnostic challenge. Tumefactive demyelinating lesion requires extensive work-up as its clinical and radiological features are often indistinguishable from other central nervous system lesions, such as tumors. Diagnosis is further complicated by the increasing recognition that tumefactive demyelinating lesions can occur alongside, evolve into, or develop from numerous conditions other than multiple sclerosis, pointing to a possible overlapping etiology. We review herein relevant studies from 2017 onwards to provide a current view on the pathogenesis, clinical and imaging findings, novel diagnostic techniques for differential diagnoses, and management of tumefactive demyelinating lesions.
摘要：
结节性脱髓鞘病变是多发性硬化症的一种变体，是诊断挑战。结节性脱髓鞘病变需要广泛的检查，因为其临床和放射学特征通常与其他中枢神经系统病变难以区分。如肿瘤。诊断变得更加复杂，因为越来越多的人认识到根癌性脱髓鞘病变可以同时发生，进化成,或者是从多发性硬化症以外的许多疾病发展而来的，指出可能重叠的病因。我们回顾了从2017年起的相关研究，以提供关于发病机理的最新观点。临床和影像学检查结果，鉴别诊断的新诊断技术，根癌性脱髓鞘性病变的处理。
